Evidence map›Paper›PMID 40470942›Full record

ArticleInfection and immunity2025

GM-CSF engages multiple signaling pathways to enhance pro-inflammatory cytokine responses in human monocytes during

Víctor R Vázquez Marrero, Madison Dresler, Mikel D Haggadone, Allyson Lu, Sunny Shin

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Víctor R Vázquez MarreroDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-5134-3244
Madison DreslerDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-6647-6392
Mikel D HaggadoneDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-7001-9132
Allyson LuDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Sunny ShinDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-5214-9577

Funding

Innate immune-mediated control of pulmonary Legionella pneumophila infectionR01AI118861 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHIN, SUNNY · 2016 to 2025
$4.6M
ST Research Education Program to Increase Diversity in Health Related ResearchR25HL084665 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI DELISSER, HORACE M, SHIN, SUNNY · 2006 to 2024
$2.2M
Defining human noncanonical inflammasome responses to Legionella pneumophilaR01AI123243 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHIN, SUNNY · 2016 to 2020
$2.0M
TNF and caspase-8-mediated control of Legionella pneumophila infectionR21AI151476 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SHIN, SUNNY · 2021 to 2022
$447k
NHLBI NIH HHS R25 HL084665NIAID NIH HHS R01 AI118861NIAID NIH HHS R01 AI123243NIAID NIH HHS R21 AI151476
6 · The paper itself

Abstract

The proinflammatory cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) is required for host defense against a wide range of pathogens. During infection with the intracellular bacterial pathogen

Indexed as

CytokinesGranulocyte-Macrophage Colony-Stimulating FactorLegionella pneumophilaLegionnaires' DiseaseMonocytesSignal TransductionHumansCytokinesGranulocyte-Macrophage Colony-Stimulating FactorAktamino acid metabolismglycolysisGM-CSFhuman monocytesLegionella pneumophilamTORC1NF-kBPI-3KTLR

Identifiers

PMID40470942
PMCPMC12234439

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.