ArticleAnnals of Indian Academy of Neurology2025
Prevalence, Risk Factors, and Psychosocial Impact of Restless Legs Syndrome in End-Stage Renal Disease Patients Undergoing Hemodialysis - A Cross-Sectional Study.
Article in Annals of Indian Academy of Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Authors' reply- Letter Regarding the Article Entitled "Prevalence, Risk Factors, and Psychosocial Impact of Restless Legs Syndrome in End-Stage Renal Disease Patients Undergoing Hemodialysis".Annals of Indian Academy of Neurology · 2026Article
- Correspondence: "Prevalence, Risk Factors, and Psychosocial Impact of Restless Legs Syndrome in End-Stage Renal Disease Patients Undergoing Hemodialysis".Annals of Indian Academy of Neurology · 2026Article
- Transcranial Sonographic Characteristics of Substantia Nigra in End-Stage Renal Disease Patients with Restless Legs Syndrome: A Diagnostic Marker Study.Diagnostics (Basel, Switzerland) · 2025Article
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Authors and funding
6 authors.
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Abstract
BACKGROUND AND
objectivesRestless legs syndrome (RLS) is common but often underdiagnosed in patients with end-stage renal disease (ESRD) undergoing hemodialysis, significantly impacting their quality of life. This study investigates the prevalence, risk factors, and psychosocial effects of RLS in this population.
methodsA cross-sectional study was conducted among 308 hemodialysis patients at a tertiary care hospital. RLS was diagnosed based on the International Restless Legs Syndrome Study Group criteria. The severity of RLS, sleep quality, and mental health were assessed using the International Restless Legs Syndrome (IRLS) Severity Score, Pittsburgh Sleep Quality Index, and Hospital Anxiety and Depression Scale. Clinical and biochemical parameters were also analyzed. Statistical significance was determined using Chi-squared and unpaired t -tests ( P < 0.05).
resultsRLS was identified in 46 patients (14.9%). Among them, 56.6% had mild symptoms, 41.3% had moderate symptoms, and 2.1% had severe symptoms. Patients with RLS were younger (50.15 ± 12.19 vs. 57.41 ± 13.43 years, P = 0.001) and had lower body weight (57.89 ± 9.64 vs. 62.78 ± 10.58 kg, P = 0.03). Anxiety and depression were significantly higher in the RLS group ( P = 0.001). Poor sleep quality was reported in 97.8% of RLS patients ( P = 0.001). Hemoglobin ( P = 0.02) and thyroid-stimulating hormone ( P = 0.03) levels also differed significantly between groups.
conclusionsRLS is highly prevalent in ESRD patients undergoing hemodialysis and is associated with significant psychosocial burden and poor sleep quality.
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