ArticleJournal of applied clinical medical physics2025
Advantages and limitations of navigation-based multicriteria optimization (MCO) in selectively sparing pharyngeal constrictor muscles in head and neck radiotherapy treatment planning.
Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Advantages and limitations of navigation-based multicriteria optimization (MCO) in selectively sparing pharyngeal constrictor muscles in head and neck radiotherapy treatment planning.Journal of applied clinical medical physics · 2025Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeSparing pharyngeal constrictor muscles (PCMs) during radiotherapy improves patient-reported swallowing function. This study aimed to explore the feasibility of integrating knowledge-based planning (KBP) with multicriteria optimization (MCO) in Eclipse v18.0 to selectively spare PCM, quantify the required trade-off in prophylactic planning target volume (PTV54) coverage, and to evaluate MCO performance.
methodTen patients previously planned with KBP for oropharyngeal cancer (65, 60, and 54 Gy in 30 fractions) were retrospectively re-planned. Clinical plans were further optimized using trade-off exploration in MCO, with a priority order: spinal cord and brainstem sparing, high-dose and intermediate-dose target coverage, PCM sparing, low-dose target coverage, parotids sparing, remaining organs at risk (OAR). Plans were evaluated based on planning target volumes dose metrics (D
resultsMCO reduced the average mean dose to the superior and middle PCM, inferior PCM, contralateral parotid, and larynx by 2.0, 3.4, 2.6, and 3.9 Gy, respectively (p < 0.05) but at the expense of HI and CI. No difference was observed in average PTV54 D
conclusionMCO effectively balances the trade-off between PCM sparing and low-dose target coverage. It may be a valuable tool in the context of personalized care.
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