Evidence map›Paper›PMID 40470593›Full record

ArticleJournal of primary care & community health

Primary Care Physician Use of Elastic Scattering Spectroscopy on Skin Lesions Suggestive of Skin Cancer.

Stephen P Merry, Ivana T Croghan, Kimberly A Dukes, Brian C McCormick, Gerard T Considine, Michelle J Duvall, Curtis T Thompson, David J Leffell

Abstract readMulticenter StudyValidation Study
In one paragraph

Article in Journal of primary care & community health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Near-Infrared Spectroscopy Combined With Skin Impedance for Detection of Skin Cancer in Primary Care.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stephen P MerryDepartment of Family Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-3816-8154
Ivana T CroghanDepartment of Internal Medicine, Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-3464-3525
Kimberly A DukesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.ORCID 0000-0002-5135-8809
Brian C McCormickHampton Family Practice, Hampton, VA, USA.ORCID 0009-0008-6009-4471
Gerard T ConsidineClare Medical Centre, Clare, SA, Australia.ORCID 0000-0002-6313-0721
Michelle J DuvallDepartment of Family Medicine, Mayo Clinic, Rochester, MN, USA.
Curtis T ThompsonDepartment of Dermatology and Department of Pathology, Oregon Health & Science University, Portland, Oregon, USA; CTA Pathology: Curtis Thompson, MD & Associates, Beaverton, OR, USA.ORCID 0000-0003-0788-346X
David J LeffellDepartment of Dermatology, Section of Dermatologic Surgery and Cutaneous Oncology, Yale School of Medicine, New Haven, CT, USA.ORCID 0009-0008-8766-3793

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the performance of noninvasive, elastic scattering spectroscopy, algorithm-powered device (DermaSensor) to detect melanoma and basal and squamous cell cancers in the primary care setting. PATIENTS &

methodsDERM-SUCCESS, a blinded, prospective, multicenter pivotal study, enrolled adult patients between August 17, 2020, and December 9, 2021, with lesions that their primary care physicians (PCPs) suspected of skin cancer at clinics in the US (n = 18) and Australia (n = 4). These lesions were assessed by PCPs and scanned with the DermaSensor device. Biopsy specimens were collected, and histopathologic analysis was performed by dermatopathologists. The diagnostic performance of the device, dermatopathologist discordance, and subgroup analyses of clinical interest were calculated.

resultsOf the 1579 skin lesions enrolled, dermatopathologic analysis identified 224 (14.2%) cancers. Device sensitivity was 95.5% (95% CI, 91.7%-97.6%) overall and 96.3% (92.9%-98.4%) for patients in the FDA-approved age group 40 years and older (90.2% for melanoma, 97.8% for basal cell carcinoma, and 97.7% for squamous cell carcinoma). Device specificity was 20.7%. The negative predictive value was 96.6%, and the positive predictive value was 16.6% (NNB 6). The device misclassified as "

conclusionsThe DermaSensor device is an easy-to-use, point-of-care, hand-held skin cancer adjunctive diagnostic device with high sensitivity and NPV to help inform PCP decision-making about skin lesions suspicious for cancer that need further evaluation and those that may be monitored.

Indexed as

Basal Cell CarcinomaCarcinoma, Squamous CellMelanomaPhysicians, Primary CareSkin NeoplasmsSpectrum AnalysisAdultAgedAged, 80 and overAlgorithmsAustraliaFemaleHumansMaleMiddle AgedPrimary Health Carebasal cell carcinomaDermaSensorelastic scattering spectroscopymelanomaprimary careskin cancersquamous cell carcinoma

Identifiers

PMID40470593
PMCPMC12144386

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.