Preferences for Nonpharmaceutical Interventions During the Endemic Phase of COVID-19: Discrete Choice Experiment.

Background: Nonpharmaceutical interventions (NPIs) are effective tools for pandemic containment but often impose significant socioeconomic consequences that intensify over time. Public support and compliance to NPIs are crucial to ensure their effectiveness. objectives: This study aimed to elicit preferences of a Singaporean population for the reintroduction of NPIs in response to the emergence of a new SARS-CoV-2 variant during the COVID-19 endemic phase. Methods: A web-based discrete choice experiment (DCE) was conducted. DCE attributes reflected key NPIs implemented in Singapore during the COVID-19 pandemic from 2020 to 2022, including mask wearing, dining restrictions, suspension of vocalization activities and large-scale events, quarantine after international travel, and mandatory vaccine boosters. Participants were recruited from a demographically representative online panel. Statistical analysis was performed using a mixed-logit model and mixed-mixed multinomial logit model. Results: A total of 1552 participants were included in the analysis. Overall preferences from the mixed-logit model showed that mask wearing was valued, both in public and indoors. Dining restrictions allowing groups of up to 5 people were preferred, but stricter dining restrictions allowing up to 2 people or no dining out were not favored. Prohibiting large-scale events was not preferred. Participants accepted quarantine at home but opposed quarantine in government facilities. Two classes emerged from the mixed-mixed logit model: class 1 ("Prefer NPIs") and class 2 ("Prefer No NPIs"). While class 1 (39%) was only opposed to a complete prohibition on dining in at food and beverage establishments, no NPIs were preferred by class 2 (61%). Both classes were not opposed to mandatory mask wearing, dining restrictions allowing groups of up to 5 people, and mandatory vaccine boosters. Sex, age, education, employment status, the number of COVID-19 vaccine shots received, and risk attitude were associated with individuals' likelihood of belonging to a specific preference group. Conclusions: Following the emergence of a new SARS-CoV-2 variant after a prolonged period of restrictions, less disruptive NPIs such as mask wearing indoors were valued by the public and should be swiftly reinstated. Adaptive strategies should be adopted for more contentious NPIs, such as strict dining restrictions and quarantine policies. Public preferences should be considered in the design and selection of NPIs for future pandemic containment strategies to enhance compliance and effectiveness.