ArticleFrontiers in bioengineering and biotechnology2025
Bioinspired piezoelectric patch design for sonodynamic therapy: a preclinical mechanistic evaluation of rotator cuff repair and functional regeneration.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Advanced engineering strategies for biomaterial scaffolds application in tendon-bone interface regeneration.Burns & trauma · 2026Review
- Mechanosensitive Ion Channels: Molecular Hubs Integrating Skeletal Muscle Adaptation and Systemic Homeostasis.International journal of biological sciences · 2026Review
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7 authors.
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Abstract
Indroduction: The rotator cuff tendon-bone interface exhibits a gradient histological composition, including graded mineral content and interwoven collagen fibers. Following rotator cuff injury repair, the lack of a compositional, structural, and functional gradient at the interface results in stress concentration and a high rate of postoperative re-tears. Piezoelectric materials, known for modulating cellular functions and promoting stem cell proliferation and differentiation, have garnered increasing attention in tissue repair applications. Methods: In this study, a biomimetic piezoelectric patch with progressive compositional and structural variations was designed and fabricated. The patch, composed of gelatin/PLGA/nHA/BTO, integrates aligned and random fiber structures. The aligned layer mimics the tendon-side structure of the rotator cuff tendon-bone interface, while the random layer replicates the bone-side structure. Results: The bioinspired patch exhibits excellent biocompatibility. The piezoelectric signals generated under ultrasound stimulation can induce osteogenic and tenogenic differentiation of stem cells, as well as regulate M2 polarization of macrophages, thereby promoting the repair and regeneration of supraspinatus tendon injury in a rabbit model of rotator cuff injury. Discussion: This study highlights the potential of biomimetic piezoelectric patches in orthopedic rotator cuff repair and offers new possibilities for developing advanced materials to regenerate the rotator cuff tendon-bone interface.
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