Evidence map›Paper›PMID 40470431›Full record

ArticleCureus2025

Ischemic Stroke After Cochlear Implantation in a Patient With an Undiagnosed Mitochondrial Disorder.

Peter Kullar, Ki Wan Park, Adam Kaufman, Peter L Santa Maria

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Peter KullarDepartment of Otolaryngology-Head and Neck Surgery, Stanford Hospital, Palo Alto, USA.
Ki Wan ParkDepartment of Otolaryngology-Head and Neck Surgery, Stanford Hospital, Palo Alto, USA.
Adam KaufmanDepartment of Otolaryngology-Head and Neck Surgery, Stanford Hospital, Palo Alto, USA.
Peter L Santa MariaDepartment of Otolaryngology-Head and Neck Surgery, Stanford Hospital, Palo Alto, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Limited reports exist on cochlear implantation in patients with syndromic hearing loss due to mitochondrial disorders. Among mitochondrial disorders, mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a notable example. MELAS is a disorder characterized by myopathy, seizures, diabetes, and focal neurological deficits, including sensorineural hearing loss. Careful optimization of risk factors and perioperative anesthetic considerations must be taken to avoid complications unique to MELAS, including metabolic and cardiac instability and an increased risk of stroke. Herein, we present the case of a 44-year-old woman with a history of bilateral sensorineural hearing loss who underwent a routine second side cochlear implantation which was complicated by ischemic stroke in the setting of severe intracranial atherosclerosis. Following the ischemic stroke, the patient underwent genetic testing, which confirmed a diagnosis of MELAS.

Indexed as

cochlear implant (ci) surgerygenetic risk factorshearing lossneuro-otologyotolaryngology

Identifiers

PMID40470431
PMCPMC12136543

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.