Evidence map›Paper›PMID 40470257›Full record

ArticleResearch square2025

Genetic Polymorphisms in Human CX3CR1-Mediated Macrophage Dysregulation are Associated with the Worsening of Hearing Loss and Cochlear Degeneration After Noise Trauma: A Study in a Humanized Mouse Model.

Dinesh Y Gawande, Sree Varshini Murali, Shriti S Thakur, Emma J Nicolaisen, Lyudmila Batalkina, Astrid E Cardona, Tejbeer Kaur

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Dinesh Y GawandeCreighton University.
Sree Varshini MuraliRutgers, The State University of New Jersey.
Shriti S ThakurRutgers, The State University of New Jersey.
Emma J NicolaisenRutgers, The State University of New Jersey.
Lyudmila BatalkinaCreighton University.
Astrid E CardonaThe University of Texas at San Antonio.
Tejbeer KaurRutgers, The State University of New Jersey.

Funding

Innate Immunity to Spiral Ganglion Neuron DegenerationR01DC019918 · NIDCD · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Tejbeer Kaur · 2022 to 2026
$2.5M
NIDCD NIH HHS R01 DC019918
6 · The paper itself

Abstract

Sensorineural hearing loss (SNHL) is characterized by cochlear inflammation, macrophage activation, and degeneration of hair cells, synapses and neuron. Macrophage-mediated inflammation in the damaged cochlea is regulated via CX3CR1-CX3CL1 signaling, where the fractalkine ligand CX3CL1 serves as a chemotactic and calming signal for macrophage activation. Furthermore, disrupted CX3CR1-CX3CL1 signaling in CX3CR1-KO and CX3CL1-KO mice leads to reduced macrophage numbers, exacerbated inflammation and loss of hair cells, ribbon synapses and neurons in the damaged cochlea. Notably, ~ 25% of the human population carry single nucleotide polymorphisms (SNPs) in the CX3CR1 gene, CX3CR1

Indexed as

CochleaCX3CR1FractalkineHair cellHearing lossInflammationMacrophageNoise traumaPolymorphismRibbon synapse

Identifiers

PMID40470257
PMCPMC12136212

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.