Evidence map›Paper›PMID 40470242›Full record

ArticleResearch square2025

Small intestinal microbial fiber metabolism dysfunction in celiac disease.

M Wulczynski, M Constante, H J Galipeau, J-J Blom, G H Rueda, N El-Chaar, D K Superdock, S Jiang, L A David, J A Murray and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

M WulczynskiFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.
M ConstanteFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.
H J GalipeauFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.
J-J BlomFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.
G H RuedaFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.
N El-ChaarFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.ORCID 0009-0002-2573-9509
D K SuperdockDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0001-5348-3307
S JiangDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.
L A DavidDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.ORCID 0000-0002-3570-4767
J A MurrayDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.
M G SuretteFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-0086-4995
D ArmstrongFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.
M I Pinto SanchezFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.
P BercikFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-8707-1781
A CamineroFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-9555-7167
E F VerduFarncombe Family Digestive Health Research Institute - McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-6346-2665

Funding

DUKE TRAINING GRANT IN DIGESTIVE DISEASES AND NUTRITIONT32DK007568 · NIDDK · DUKE UNIVERSITY · PI Katherine Garman, Rodger A. Liddle · 1988 to 2026
$5.6M
Personalizing prebiotic therapies that target human gut microbiotaR01DK116187 · NIDDK · DUKE UNIVERSITY · PI Lawrence Anthony David · 2018 to 2026
$3.7M
Using DNA sequencing to assess dietary species richnessR01DK128611 · NIDDK · DUKE UNIVERSITY · PI Lawrence Anthony David · 2022 to 2026
$2.9M
NIDDK NIH HHS R01 DK116187NIDDK NIH HHS R01 DK128611NIDDK NIH HHS T32 DK007568
6 · The paper itself

Abstract

Celiac disease (CeD) is an immune-mediated condition driven by dietary gluten resulting in small intestinal mucosal inflammation and injury, along with myriads of symptoms. The only treatment is a lifelong gluten-free diet (GFD) and although most patients improve, the restriction can lead to nutrient deficiencies including fiber. While duodenal microbiota is altered in CeD, its fiber metabolic capacity is unknown. Here we show that both active and treated CeD patients had impaired microbial fiber metabolism in the small intestine which associates with depletion of the carbolytic taxa

Identifiers

PMID40470242
PMCPMC12136232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.