ArticleResearch square2025
Transcriptomic Signature-Guided Depletion of Intermediate Alveolar Epithelial Cells Ameliorates Pulmonary Fibrosis in Mice.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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11 authors.
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Abstract
Single-cell RNA sequencing (scRNA-seq) analyses of human and murine models of pulmonary fibrosis have uncovered multiple novel cell states involved in lung repair and regeneration, including an intermediate epithelial cell state identified as the KRT5-/KRT17+ aberrant basaloid cells in humans and the cytokeratin 8-positive alveolar differentiation intermediate (Krt8+ ADI) in mice. However, the specific contributions of these transitional cells to fibrogenesis remain poorly understood. In this study, we introduce a novel RNA-sensing-dependent protein translation technology that enables selective targeting and functional interrogation of Krt8+ ADI cells both
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Registered trials
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