ArticleResearch square2025
Simian Immunodeficiency Virus-Infected Macrophage Traffic Out of the Central Nervous System.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Resolving inflammation: The impact of antiretroviral therapy on macrophage traffic in and out of the CNS.PLoS pathogens · 2025Article
Corrections and comments
- Updated bySPION2025
Authors and funding
6 authors.
Funding
Abstract
We use intracisternal (i.c.) injection of fluorescent-superparamagnetic iron oxide nanoparticles (SPION) in SIV-infected monkeys that labeled CNS CD68-CD163-CD206 perivascular, meningeal, and choroid plexus (CP) macrophages. SPION + CD163 + macrophages are also found in the optic nerves, nasal septum, and cribriform plate - potential sites-paths of macrophage exit. Outside the CNS CD163 + SPION + macrophages labeled in the CNS are in deep cervical lymph node (dCLN), spleen, dorsal root ganglia (DRG). CD163 + SPION + CNS macrophages are abundant 24 hours p.i. in normal animals and decrease over time without CNS inflammation, but accumulate with SIV infection and inflammation. Greater numbers of SPION + macrophages traffic out of the CNS in normal animals and decrease with infection. Productively infected, SPION + macrophages are found in the CNS and dCLN, spleen, and DRG of infected animals 7-14 days post i.c. injection. These data are consistent with SPION + macrophages, some of which are viral infected, trafficking out of the CNS.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.