ArticleResearch square2025
Multi-trait Analysis of GWAS Expands Eosinophilic Esophagitis Genetic Susceptibility and Polygenic Risk Scores.
Michael P Trimarchi, Bahram Namjou-Khales, Netali Ben-Baruch Morgenstern, Mark Rochman, Xiaoting Chen, Garrett Osswald, John Besse, Molly Shook, Julie Caldwell, Michael Lape and 8 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
18 authors.
Bahram Namjou-KhalesCincinnati Children's Hospital Medical Center.
Netali Ben-Baruch MorgensternCincinnati Children's Hospital Medical Center.
Mark RochmanCincinnati Children's Hospital Medical Center.
Xiaoting ChenCincinnati Children's Hospital Medical Center.
Garrett OsswaldCincinnati Children's Hospital Medical Center.
John BesseCincinnati Children's Hospital Medical Center.
Molly ShookCincinnati Children's Hospital Medical Center.
Julie CaldwellCincinnati Children's Hospital Medical Center.
Michael LapeCincinnati Children's Hospital Medical Center.
Tetsuo ShodaCincinnati Children's Hospital Medical Center.
Matthew T WeirauchCincinnati Children's Hospital Medical Center.
Melanie RuffnerChildren's Hospital of Philadelphia.
Gregory ConstantineNational Institute of Allergy and Infectious Diseases.
Lisa J MartinCincinnati Children's Hospital Medical Center.
Leah C KottyanCincinnati Children's Hospital Medical Center.
Marc E RothenbergCincinnati Children's Hospital Medical Center.
Consortium of Eosinophilic Gastrointestinal Disease Researchers
Funding
The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Rhonda Szczesniak · 2019 to 2026
$51.2MTSLP, IL-9-producing mucosal mast cells, and allergic inflammationU19AI070235 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Gurjit K. Khurana Hershey · 2006 to 2026
$31.3MTRAINING (CAREER DEVELOPMENT) COMPONENTU54AI117804 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI JONATHAN Micheal SPERGEL · 2014 to 2026
$18.5MResearch Project 3: Role of Posttranslational Protein Modifications in the Pathogenesis of Ebola Virus DiseaseP01AI150585 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BUKREYEV, ALEXANDER · 2021 to 2025
$11.3MHLA GENE COMPLEMENTATION IN PRIMARY SJOGREN'S AND LUPUSR01AI024717 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI KOTTYAN, LEAH CLAIRE, WEIRAUCH, MATTHEW TYSON · 1987 to 2025
$7.8MTissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7MPolygenic Risk Scores for Healthier African American FamiliesU01HG011172 · NHGRI · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan, LISA J MARTIN · 2020 to 2026
$7.2MGene Regulation as a Foundation for Autoimmune Disease PreventionU01AI130830 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI WEIRAUCH, MATTHEW TYSON · 2017 to 2021
$7.2MBIOCHEMICAL AND GENETIC ANALYSIS OF NOTCH SIGNALINGR01GM055479 · NIGMS · WASHINGTON UNIVERSITY · PI KOPAN, RAPHAEL, WEIRAUCH, MATTHEW TYSON · 1996 to 2021
$6.4MGenetic and Immunological Dissection of Eosinophilic EsophagitisR01AI124355 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI Marc E. Rothenberg · 2015 to 2026
$5.9MDynamic regulatory network models of human response to influenza virusU01AI150748 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI MARAZZI, IVAN, MIRALDI, EMILY · 2020 to 2024
$5.8MBinding of Epstein Barr Virus EBNA2 Unifies Multiple Sclerosis Genetic MechanismsR01NS099068 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan, Matthew Tyson Weirauch · 2017 to 2026
$4.2MNCATS NIH HHS U2C TR002818NHGRI NIH HHS R01 HG010730NHGRI NIH HHS U01 HG011172NHGRI NIH HHS U24 HG013078NIAID NIH HHS P01 AI150585NIAID NIH HHS R01 AI024717NIAID NIH HHS R01 AI124355NIAID NIH HHS R01 AI141569NIAID NIH HHS R01 AI148276NIAID NIH HHS U01 AI130830NIAID NIH HHS U01 AI150748NIAID NIH HHS U01 AI181966NIAID NIH HHS U19 AI070235NIAID NIH HHS U54 AI117804NIAMS NIH HHS P30 AR070549NIAMS NIH HHS R01 AR073228NIDDK NIH HHS R01 DK107502NIGMS NIH HHS R01 GM055479NINDS NIH HHS R01 NS099068
6 · The paper itselfAbstract
Atopic diseases, including eosinophilic esophagitis (EoE), are driven in part by genetic susceptibility. We performed a genome-wide association study (GWAS) of 1,757 EoE and 14,467 population controls, identifying 11 independent genetic risk variants spanning 8 EoE risk loci (p < 5×10
Indexed as
AllergyEosinophilic EsophagitisGene Expression ProfilingGenome-wide Association Studies
Identifiers
PMID40470207
PMCPMC12136185
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