ArticleResearch square2025
Inhibition of CDK8 rescues impaired ischemic fracture healing.
Christina A Capobianco, Michelle J Song, Easton C Farrell, Alexander J Knights, Karen Kessell, Alexis Donneys, Jeanna T Schmanski, Luke R Schroeder, Mengqian Chen, Igor B Roninson and 3 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
13 authors.
Christina A CapobiancoUniversity of Michigan-Ann Arbor.
Michelle J SongUniversity of Michigan-Ann Arbor.
Easton C FarrellUniversity of Michigan-Ann Arbor.
Alexander J KnightsUniversity of Michigan-Ann Arbor.
Karen KessellUniversity of Michigan-Ann Arbor.
Alexis DonneysUniversity of Michigan-Ann Arbor.
Jeanna T SchmanskiUniversity of Michigan-Ann Arbor.
Luke R SchroederUniversity of Michigan-Ann Arbor.
Mengqian ChenUniversity of South Carolina.
Igor B RoninsonUniversity of Michigan-Ann Arbor.
Yadav WagleyUniversity of Michigan-Ann Arbor.
Tristan MaerzUniversity of Michigan-Ann Arbor.
Kurt D HankensonUniversity of Michigan-Ann Arbor.
Funding
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2MPrecision Mapping of Knee Pain in Osteoarthritis: Understanding differences between pain with activity and restUC2AR082186 · NIAMS · RUSH UNIVERSITY MEDICAL CENTER · PI LOTZ, MARTIN K, MALFAIT, ANNE-MARIE · 2022 to 2025
$11.9MStructure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MNotch Signaling and Bone Fracture HealingR01AR055607 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Kurt David Hankenson, IVO Kalajzic · 2011 to 2026
$6.3MRegulators of Ischemic Fracture HealingR01AR066028 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HANKENSON, KURT DAVID · 2015 to 2020
$2.7MSustained Biomaterial-mediated Inhibition of R-spondin 2 to Target Pathological Wnt Signaling in Post-Traumatic OsteoarthritisR01AR080035 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kurt David Hankenson · 2022 to 2026
$2.5MCTSA Predoctoral T32 at the University of MichiganT32TR004371 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VICKI L ELLINGROD, MICHAEL Allan HOLINSTAT · 2023 to 2026
$2.2MBioerodible corticosteroid microparticle-drug as an intra-articular drug delivery system for osteoarthritis therapyR21AR080502 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ENIOLA-ADEFESO, OMOLOLA, MAERZ, TRISTAN · 2022 to 2023
$405kTargeting Pathological Angiogenesis after Joint InjuryR21AR076487 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALFORD, ANDREA I, MAERZ, TRISTAN · 2021 to 2021
$378kAutonomous RUNX2 suppression in genetically modified stem cell-derived chondrocytes as a disease modifying therapeutic for PTOAR21AR082016 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLEMAN, RHIMA, MAERZ, TRISTAN · 2023 to 2024
$356kFibrosis, inflammation, and osteophyte formation in post-traumatic osteoarthritisK99AR081894 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KNIGHTS, ALEXANDER JOHN · 2023 to 2024
$206kNCATS NIH HHS T32 TR004371NCI NIH HHS P30 CA046592NIAMS NIH HHS K99 AR081894NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR055607NIAMS NIH HHS R01 AR066028NIAMS NIH HHS R01 AR080035NIAMS NIH HHS R21 AR076487NIAMS NIH HHS R21 AR080502NIAMS NIH HHS R21 AR082016NIAMS NIH HHS UC2 AR082186
6 · The paper itselfAbstract
Annually, 10% of 15 million bone fractures in the US fail to heal, and fractures with compromised blood flow, i.e. ischemia, are five times more likely to become nonunions. While ischemia is known to impair healing, the cellular and molecular mechanisms underlying this deficiency are unclear. Wild-type mice with surgically-induced ischemia underwent tibia fractures, and single-cell RNA-sequencing was performed on calluses at days 4 and 7 post-fracture. We observed delayed chondrogenic differentiation and upregulation of Cyclin-Dependent Kinase 8 (
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PMID40470203
PMCPMC12136223
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