ArticleResearch square2025
Mixed-methods Study of the Effect of Chemotherapy-induced Peripheral Neuropathy SymptomPermanence on Patient's Willingness to Alter Neurotoxic Chemotherapy Treatment.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect from taxane and platinum chemotherapy, with symptoms that can persist for years after treatment and significantly diminish quality of life. This study aimed to evaluate how the potential permanence of CIPN influences patient preferences for continuing vs. altering neurotoxic chemotherapy. Methods: A mixed-methods approach was adopted, which included surveys and semi-structured interviews. During treatment, surveys used the EORTC QLQ-CIPN20 questionnaire to assess CIPN severity and patient preferences for continuing, altering, or discontinuing chemotherapy under hypothetical scenarios of temporary vs. permanent CIPN. Post-treatment interviews investigated patients' perceptions of altering treatment due to temporary or permanent CIPN. Results: Survey data from 66 participants revealed that CIPN permanence considerably increased the likelihood of patients preferring to alter treatment (Odds ratio [OR] = 29.14 [95% confidence interval: 15.31-55.46], p < 0.001). Among 29 post-interviewees, 62% decided to continue with their present regimen despite CIPN, citing treatment efficacy and a lack of concern for CIPN. However, in a hypothetical scenario that their CIPN would be permanent, only 8% preferred to continue treatment without alterations, whereas 50% preferred to alter treatment and 13% to discontinue treatment. Conclusion: CIPN permanence substantially influences patient preferences for treatment decisions. Improved communication between oncology teams and patients regarding risks of permanent CIPN is essential to support shared decision making to achieve patient's preferred therapeutic outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.