ArticleResearch square2025
Regulation of polyamine interconversion enzymes affects α-Synuclein levels and toxicity in a Drosophila model of Parkinson's Disease.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Parkinson's Disease (PD) is a prevalent neurodegenerative disorder characterized by the accumulation and aggregation of α-synuclein as a defining pathological hallmark. Misfolding and aggregation of α-synuclein disrupt cellular homeostasis, hinder mitochondrial function, and activate neuroinflammatory responses, ultimately resulting in neuronal death. Recent biomarker studies have reported a significant increase in the serum concentrations of three L-ornithine-derived polyamines, correlating with PD progression and its clinical subtypes. However, the precise role of polyamine pathways in PD pathology remains poorly understood. In this study, we explored the impact of modifying polyamine-interconversion enzymes (PAIE) on the α-synucleinopathy phenotype in a
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