Evidence map›Paper›PMID 40470154›Full record

ArticleERJ open research2025

Characterising dysfunctional breathing seen in post-acute sequelae of SARS-CoV-2 using approximate entropy.

Erin Eschbach, Benjamin H Natelson, Donna M Mancini, Dane B Cook, Kevin Rurak, Melissa Miranda, Beno W Oppenheimer, David M Rapoport, Ankit Parekh

Abstract read
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Erin EschbachIcahn School of Medicine at Mount Sinai, Department of Pulmonary, Critical Care, and Sleep Medicine, New York, NY, USA.
Benjamin H NatelsonIcahn School of Medicine, Department of Neurology, New York, NY, USA.
Donna M ManciniIcahn School of Medicine, Department of Cardiology, New York, NY, USA.
Dane B CookWilliam S. Middleton Memorial Veteran's Hospital, Madison, WI, USA.
Kevin RurakNational Jewish Health, Department of Pulmonary Critical Care and Sleep Medicine, Denver, CO, USA.
Melissa MirandaIcahn School of Medicine at Mount Sinai, Department of Pulmonary, Critical Care, and Sleep Medicine, New York, NY, USA.
Beno W OppenheimerNYU Grossman School of Medicine, Department of Pulmonary, Critical Care, and Sleep Medicine, New York, NY, USA.
David M RapoportIcahn School of Medicine at Mount Sinai, Department of Pulmonary, Critical Care, and Sleep Medicine, New York, NY, USA.
Ankit ParekhIcahn School of Medicine at Mount Sinai, Department of Pulmonary, Critical Care, and Sleep Medicine, New York, NY, USA.

Funding

CSRD VA IK6 CX002369
6 · The paper itself

Abstract

Rationale: Dysfunctional breathing (DB) is a commonly identified abnormality in post-acute sequelae of SARS-CoV-2 (PASC) patients undergoing cardiopulmonary exercise testing (CPET), and is potentially a contributor to ongoing symptoms. Currently, this oscillating, irregular breathing pattern is identified by visual observation of CPET data by an experienced interpreter, which is subjective. We hypothesise that approximate entropy (ApEn), a regularity statistic that quantifies the unpredictability of time-series data can reliably distinguish DB from normal breathing states. Methods: Breath-by-breath CPET data were obtained for 82 PASC subjects and 25 controls. CPETs were visually analysed for DB prior to analysis. Minute ventilation ( Results: The ApEn Conclusions: Identifying DB on CPET requires visual recognition, which has limitations. ApEn

Identifiers

PMID40470154
PMCPMC12134922

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.