ArticleJHEP reports : innovation in hepatology2025
Macrophage-derived IL-15 imprints peritoneal TRM-like CD8 T cells in cirrhosis and spontaneous bacterial peritonitis.
Article in JHEP reports : innovation in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Uncovering immune dysfunction in ACLF: Cellular mechanisms, molecular pathways, and therapeutic frontiers.Journal of hepatology · 2026Review
- Remodeling mechanisms and intervention strategies of the oral mucosal immune barrier.Frontiers in immunology · 2026Review
- The Janus face of tissue-resident memory T cells: dual programming in tumor immune surveillance and autoimmune pathology.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & Aims: Tissue-resident memory T cells (TRMs) are long-lived cells poised for rapid immune responses to pathogens. This study assesses whether peritoneal CD8 T cells from patients with cirrhosis exhibit TRM-like functionalities, focusing on how inflammatory events shape phenotype and function. Methods: Peritoneal CD8 T cell subsets from patients with decompensated cirrhosis were analysed using mass cytometry, flow cytometry, RT-qPCR, single-cell RNA sequencing, Results: Unsupervised mass cytometry and subsequent flow cytometry validation confirmed the peritoneal abundance of CD103+ CD69+ CD8+ memory T cells in ascites compared with blood (2.2% Conclusions: A subset of peritoneal CD8 T cells exhibits TRM-like traits and responds to macrophage-derived cytokines during peritoneal inflammation. TRM-like cells retain potent cytotoxic and proinflammatory responses after SBP resolution, underscoring their role in modulating peritoneal immunity and inflammation in cirrhosis. Impact and implications: Patients with decompensated cirrhosis exhibit impaired immune responses increasing the risk of spontaneous bacterial peritonitis. This study provides insight into a subset of human peritoneal CD8 T cells in patients with decompensated cirrhosis that have a long-lived and tissue-resident phenotype capable of effectively fighting recognised pathogens within a short period with the help of IL-15 produced by activated macrophages in a bystander fashion. This knowledge has the potential to improve immunomodulatory therapies aiming to enhance peritoneal immune surveillance, and by targeting TRM-like cells and/or IL-15 signalling pathways. In addition, high concentrations of soluble immune checkpoints in ascites should be considered when applying immune checkpoint inhibitors in decompensated cirrhosis.
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