Evidence map›Paper›PMID 40470062›Full record

ArticleNature and science of sleep2025

Relationship between Serum Neurotransmitters and Cognitive Impairment in Adults with Obstructive Sleep Apnea.

Fangli Yang, Simin Zhu, Xinru Lv, Yanuo Zhou, Zitong Wang, Chendi Lu, Zihan Xia, Haiqin Liu, Jin Hou, Jing Yan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fangli Yang *Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Simin Zhu *Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.ORCID 0009-0003-3308-022X
Xinru LvDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Yanuo ZhouDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Zitong WangDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Chendi LuDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Zihan XiaDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Haiqin LiuDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Jin HouDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Jing YanDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.ORCID 0000-0001-8934-9222
Jingguo ChenDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Hui LvDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Yewen ShiDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.
Xiaoyong RenDepartment of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The primary aim of this study was to investigate the serum levels of acetylcholine (Ach), norepinephrine (NE), dopamine (DA), and 5-hydroxytryptamine (5-HT) in two groups: those with obstructive sleep apnea (OSA) and cognitive impairment (CI) and those with OSA but no cognitive impairment (NCI). Methods: A total of 30 adults (CI) and 75 adults (NCI) who completed polysomnography examinations between December 2023 and September 2024 were enrolled in the study. Enzyme-linked immunosorbent assays were used to measure serum levels of Ach, NE, DA, and 5-HT. Correlation and pooled analyses were conducted to assess the relationship between cognitive scores and four serological indicators. Logistic regression was performed to identify risk factors for cognitive impairment. Results: Serum DA levels were higher in the CI group (275.10, 216.73-426.91, pg/mL) than in the NCI group (219.69, 138.46-261.97, pg/mL) ( Conclusion: Serum DA levels were associated with the severity of cognitive impairment in adults diagnosed with OSA and might serve as a potential, objective biomarker for identifying cognitive dysfunction in this population.

Indexed as

5-hydroxytryptamineacetylcholinecognitive dysfunctiondopamineneurotransmitternorepinephrineobstructive sleep apnea

Identifiers

PMID40470062
PMCPMC12134008

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.