Enhancing gastroenterology with multimodal learning: the role of large language model chatbots in digestive endoscopy.

Introduction: Advancements in artificial intelligence (AI) and large language models (LLMs) have the potential to revolutionize digestive endoscopy by enhancing diagnostic accuracy, improving procedural efficiency, and supporting clinical decision-making. Traditional AI-assisted endoscopic systems often rely on single-modal image analysis, which lacks contextual understanding and adaptability to complex gastrointestinal (GI) conditions. Moreover, existing methods struggle with domain shifts, data heterogeneity, and interpretability, limiting their clinical applicability. Methods: To address these challenges, we propose a multimodal learning framework that integrates LLM-powered chatbots with endoscopic imaging and patient-specific medical data. Our approach employs self-supervised learning to extract clinically relevant patterns from heterogeneous sources, enabling real-time guidance and AI-assisted report generation. We introduce a domain-adaptive learning strategy to enhance model generalization across diverse patient populations and imaging conditions. Results and discussion: Experimental results on multiple GI datasets demonstrate that our method significantly improves lesion detection, reduces diagnostic variability, and enhances physician-AI collaboration. This study highlights the potential of multimodal LLM-based systems in advancing gastroenterology by providing interpretable, context-aware, and adaptable AI support in digestive endoscopy.