Evidence map›Paper›PMID 40469753›Full record

ArticleMolecular therapy. Methods & clinical development2025

Methods for cell- and tissue-specific DNA aptamer selection.

Brandon A Wilbanks, Caroline D Doherty, Keenan S Pearson, Sonia Jain, Jann N Sarkaria, L James Maher

Abstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brandon A WilbanksDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Caroline D DohertyDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, USA.
Keenan S PearsonDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.
Sonia JainDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA.
Jann N SarkariaDepartment of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA.
L James MaherDepartment of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine and Science, Rochester, MN 55905, USA.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
MSTP at Mayo Clinic RochesterT32GM145408 · NIGMS · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN, LISA A SCHIMMENTI · 2023 to 2026
$4.7M
Fundamental and applied studies of nucleic acidsR35GM143949 · NIGMS · MAYO CLINIC ROCHESTER · PI LOUIS JAMES MAHER · 2022 to 2026
$1.9M
In vivo SELEX strategies to identify potent aptamer-drug conjugates for glioblastomaR61NS128071 · NINDS · MAYO CLINIC ROCHESTER · PI MAHER, LOUIS JAMES, SARKARIA, JANN N. · 2023 to 2024
$801k
NCATS NIH HHS UL1 TR000135NIGMS NIH HHS R35 GM143949NIGMS NIH HHS T32 GM145408NINDS NIH HHS R61 NS128071
6 · The paper itself

Abstract

Aptamers are folded single-stranded DNA or RNA molecules with high affinity for target small molecules, proteins, cells, or tissues. Affinity arises from the three-dimensional structure of the aptamer. Many significant advancements in oligonucleotide selection strategies have been made since the first foundational reports of

Indexed as

aptamer characterizationcell selectiondeep sequencingDNA aptamerin vivo selection

Identifiers

PMID40469753
PMCPMC12134599

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.