Evidence map›Paper›PMID 40469737›Full record

ArticleFrontiers in microbiology2025

Toward an effective delivery system of a microbial sink of the uremic toxin, p-cresol; an

Prakit Saingam, Rosita Rasyid, Britt Abrahamson, Thomas J Lie, Bruce J Godfrey, Jonathan Himmelfarb, Mari K H Winkler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Microbiota and kidney disease: the road ahead.Nature reviews. Nephrology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Prakit SaingamDepartment of Civil and Environmental Engineering, University of Washington, Seattle, WA, United States.
Rosita RasyidDepartment of Microbiology, University of Washington, Seattle, WA, United States.
Britt AbrahamsonDepartment of Civil and Environmental Engineering, University of Washington, Seattle, WA, United States.
Thomas J LieDepartment of Civil and Environmental Engineering, University of Washington, Seattle, WA, United States.
Bruce J GodfreyDepartment of Civil and Environmental Engineering, University of Washington, Seattle, WA, United States.
Jonathan HimmelfarbKidney Research Institute, University of Washington, Seattle, WA, United States.
Mari K H WinklerDepartment of Civil and Environmental Engineering, University of Washington, Seattle, WA, United States.

Funding

Therapeutic bubble tea: Preventing the formation of uremic toxins with hydrogel immobilized microbesR01DK130815 · NIDDK · UNIVERSITY OF WASHINGTON · PI Mari Winkler · 2022 to 2026
$2.2M
NIDDK NIH HHS R01 DK130815
6 · The paper itself

Abstract

Individuals with chronic kidney disease (CKD) suffer from uremia, a condition characterized by the accumulation of uremic toxin in the blood. The aromatic uremic toxin p-cresol, a byproduct of tyrosine fermentation in the gut, binds to plasma albumin and cannot be removed with dialysis. However, the ingestion of densified p-cresol degrading microorganisms encapsulated in protective hydrogel beads could provide a therapeutic benefit by removing p-cresol from the colon. In this study the p-cresol degradation capacity of a known anaerobic, p-cresol degrading microorganism,

Indexed as

hydrogel encapsulationintestinal p-cresol removaloral delivery methodp-cresol degrading microorganismuremic toxin

Identifiers

PMID40469737
PMCPMC12136493

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.