ArticleFrontiers in microbiology2025
Correlation of the intestinal flora and its metabolites with the colonic transport function in functional constipation.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bibliometric and visual analysis of gut microbiota research in functional bowel disorders from 2016 to 2025.Frontiers in medicine · 2026Pooled it
- Sunflower-Derived Pectin Oligogalacturonides Promote Defecation in Mice.Foods (Basel, Switzerland) · 2026Article
- Comparative Effects of Live and Heat-KilledJournal of microbiology and biotechnology · 2026Article
- Microbiome-Informed Precision Electroconvulsive Therapy: Oral-Gut-Immune Signatures and Seizure Biology as Candidate Predictors of Response-A Narrative Review.Biomedicines · 2026Review
- Therapeutic efficacy of Jichuan decoction in slow-transit constipation: focus on gut microbiota modulation.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Sodium-glucose cotransporter 2 inhibitors and constipation: a two-sample mendelian randomization study.Frontiers in pharmacology · 2026Article
- The role of theFrontiers in microbiology · 2026Review
- Gut microbiota and constipation: from causal evidence to therapeutic strategies-a state-of-the-art narrative review.Frontiers in microbiology · 2026Review
- Microbiota-immune crosstalk in the regulation of intestinal motility in constipation.Frontiers in microbiology · 2026Review
- Molecular mechanisms and clinical applications of gut microbiota-derived bioactive compounds in metabolic dysfunction-associated fatty liver disease.Frontiers in immunology · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Functional constipation (FC) is a clinically frequent intestinal disorder. A growing body of evidence emphasizes the link between intestinal microecological imbalance and constipation. However, the microbiota composition associated with FC and the mechanisms by which metabolites influence gut motility remain poorly understood. Methods: Stool samples were collected from 60 participants (20 FC patients with delayed colonic transit time, 20 FC patients with normal colonic transit time, and 20 healthy controls), and macrogenomics and metabolomics were used to assess the differences in the microbiota and metabolite composition of different colonic transit functions in FC. In addition to assessing clinical symptoms, this study aimed to better understand how intestinal flora contributed to impaired gut motility in FC patients. Results: Significant microbiota taxonomic differences were observed across different gut dynamics in FC; Conclusion: The identified differences in the composition and metabolites of different colonic transmission-dynamic microbiota in FC further our understanding of the underlying mechanisms involved in FC pathogenesis and may provide new insights into diagnostics and therapeutic interventions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.