Evidence map›Paper›PMID 40469718›Full record

ArticleFrontiers in microbiology2025

Effects of dietary formic acid polymer supplementation on growth performance, blood parameters, and intestinal health in lipopolysaccharide-challenged broilers.

Guohui Zhou, Yilin Ge, Yuemeng Fu, Changfei An, Changjin Li, Yang Li, Weiren Yang, Ning Jiao, Jiali Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guohui Zhou *Key Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.
Yilin Ge *SDU-ANU Joint Science College, Shandong University, Wenhuaxilu, Weihai, China.
Yuemeng FuKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.
Changfei AnBureau of Agriculture and Rural Affairs, Jiangbei Watertown Resort District, Liaocheng, China.
Changjin LiKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.
Yang LiKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.
Weiren YangKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.
Ning JiaoKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.
Jiali ChenKey Laboratory of Efficient Utilization of Non-grain Feed Resources (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Shandong Provincial Key Laboratory of Animal Nutrition and Efficient Feeding, College of Animal Science and Technology, Shandong Agricultural University, Tai'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This experiment was performed to investigate the impacts of formic acid polymer (FAP) supplementation to the diet on the growth performance, blood metabolites, as well as intestinal barrier function related indicators of broilers under lipopolysaccharide (LPS) stimulation. A total of 450 1-day-old male Arbor Acres broilers with similar body weights were assigned to one of three experimental groups: control (CON) group, basal diet; LPS group, basal diet with LPS (1 mg/kg body weight) challenge; LPS+FAP group, basal diet supplemented with FAP (1,000 mg/kg) and LPS (1 mg/kg body weight) challenge. Each group had 6 replicates of 25 broilers. LPS was injected on days 17, 19, and 21. Samples were collected on day 21, 3 h post-challenge. The experiment lasted 21 days. LPS treatment reduced growth performance, immune function, and caused systemic inflammation, intestinal barrier damage, and microbiota dysbiosis in broilers. However, FAP supplementation significantly reversed these effects by reducing the feed-to-gain ratio and serum levels of interleukin (IL)-1β and tumor necrosis factor-α (

Indexed as

broilerformic acidgut microbiotainflammationintestinal barrier

Identifiers

PMID40469718
PMCPMC12133873

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.