ArticleFrontiers in aging2025
Increasing age in men is negatively associated with sperm quality and DNA integrity but not pregnancy outcomes in assisted reproductive technology.
Article in Frontiers in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Physalis polysaccharide-sericin nanocarriers for controlled alpha-lipoic acid delivery and improved human sperm cryopreservation.Scientific reports · 2026Article
- Seasonal trends in sperm quality in Denmark and Florida.Reproductive biology and endocrinology : RB&E · 2026Observational
- Clinical Implications of Paternal Age in Assisted Reproduction: Integrating Sperm Epigenetic Evidence.Journal of clinical medicine · 2026Review
- Association of sperm DNA fragmentation with abstinence duration, seminal oxidative stress and age: a call to consider abstinence in andrological diagnostics.Frontiers in urology · 2026Article
- Exploring the knowledge, attitudes, and perceptions of young men towards fertility in the UK: A cross-sectional survey.PloS one · 2026Article
- Impact of Clinical and Treatment Factors on Clinical Pregnancy and Live Birth in IVF/ICSI-ET: A Retrospective Cohort Study.International journal of general medicine · 2026Article
- Association of semen leukocytes with sperm DNA fragmentation in a clinical cohort.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the fertility risks for older males such as infertility and reduced success rates are on the rise, an increasing number of individuals are turning to Assisted Reproductive Technology (ART) to have offspring. However, the influence of paternal age on fertility and pregnancy outcomes in ART cycles remains ambiguous. Here, we analyzed the sperm quality of 6,805 samples and DNA fragmentation index (DFI) of 1,253 samples from Chinese males aged 20-63 years old. Our findings demonstrated that sperm volume, progressive motility, and total motility significantly decline, while sperm DFI increases as paternal age advances. Additionally, by studying 1,205 cases undergoing ART treatment, we discovered that male age and sperm quality do not exhibit a pronounced impact on ART outcomes. Our study has disclosed that sperm quality and DFI are inversely correlated with increasing male age. Our data further suggest that male ages do not significantly affect ART outcomes, which should offer instructive references for ART practice involving older males.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.