Evidence map›Paper›PMID 40469532›Full record

ArticleInternational journal of clinical and health psychology : IJCHP

Slow-wave sleep, oxygen desaturation, and memory consolidation in sleep-disturbed individuals.

Yi-Chun Kuan, Hsin-Wei Lin, Cheng-Chang Yang, Jung-Lung Hsu, Wen-Te Liu, Chaur-Jong Hu, Arnab Majumdar, Yi-Chih Lin, Chih-Wei Peng, Cheng-Yu Tsai

Abstract read
In one paragraph

Article in International journal of clinical and health psychology : IJCHP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Analytical amplitude/phase markers for neurological sleep apnea events.Neurobiology of sleep and circadian rhythms · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi-Chun KuanSleep Center, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235041, Taiwan.
Hsin-Wei LinSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Cheng-Chang YangDepartment of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235041, Taiwan.
Jung-Lung HsuDepartment of Neurology, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan.
Wen-Te LiuSleep Center, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235041, Taiwan.
Chaur-Jong HuSleep Center, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235041, Taiwan.
Arnab MajumdarDepartment of Civil and Environmental Engineering, Imperial College London, London, UK.
Yi-Chih LinSleep Center, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235041, Taiwan.
Chih-Wei PengTaipei Neuroscience Institute, Taipei Medical University, Taipei 110301, Taiwan.
Cheng-Yu TsaiSleep Center, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235041, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Slow-wave sleep (SWS) plays a crucial role in memory consolidation, yet its disruption in obstructive sleep apnea (OSA) remains poorly understood. This study investigates the relationship between SWS characteristics, nocturnal oxygen desaturation, and memory performance in individuals with sleep disturbances. This cross-sectional study included 49 participants with memory complaints and sleep disturbances who underwent overnight polysomnography (PSG) and cognitive assessments to determine the presence and severity of OSA. SWS parameters, including the slow-wave index, amplitude, and duration, were extracted from PSG data alongside the apnea-hypopnea index (AHI) and oxygen desaturation index (ODI-3 %). Memory consolidation was assessed pre- and post-sleep using the Word Sequence Learning Test (WSLT), with the WSLT-Memory Index Score (WSLT-MIS) as the primary outcome measure. Multiple linear regression models adjusted for age, BMI, and education were used to analyze associations between sleep parameters and memory outcomes. Higher ODI-3 % and AHI were significantly associated with poorer memory consolidation, as indicated by lower WSLT-MIS scores (p < 0.05). AHI during NREM sleep was more strongly associated with poorer memory consolidation compared to AHI during REM sleep. Conversely, a higher slow-wave index was positively correlated with better WSLT-MIS scores and retention rates (p < 0.05). These findings highlight the critical role of SWS in memory consolidation and the detrimental effects of OSA-related sleep disturbances. While CPAP therapy remains the standard treatment for improving oxygenation and reducing sleep fragmentation in OSA, additional strategies aimed at enhancing SWS may further support cognitive function. Longitudinal studies and neuroimaging approaches are needed to better understand the mechanisms linking SWS enhancement and cognitive health.

Indexed as

Memory consolidationObstructive sleep apneaPolysomnographySlow-wave sleep

Identifiers

PMID40469532
PMCPMC12133691

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.