ReviewAnimal cells and systems2025
The role of interleukin-17 in neurological disorders.
Review in Animal cells and systems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Small extracellular vesicles proteome reveals persistent inflammatory and coagulopathic dysregulation in long-COVID.Frontiers in immunology · 2026Article
- Longitudinal immune profiling demonstrates persistent MAIT cell reduction and temporal cytokine alterations after aneurysmal subarachnoid hemorrhage.Frontiers in neurology · 2026Observational
- Systemic inflammatory response drives post-cardiac arrest multi-organ injury via IL-17 signaling in murine and porcine models.Frontiers in immunology · 2026Article
- Long-term rapamycin treatment suppresses IL-17-producing gamma delta T cells and blunts neuroinflammation in aging.PloS one · 2026Article
- Alpha-lipoic acid ameliorates nab-paclitaxel-induced peripheral neuropathy by inhibiting IL-17 signaling pathway.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
In recent years, the intricate relationship between the immune system and neurological disorders has garnered significant attention. While the central nervous system had long been perceived as immunologically privileged, emerging research has revealed complex interactions among immune cells, inflammatory mediators, and neural components that collectively influence the pathogenesis and progression of various neurological disorders. This comprehensive review explores the crucial role of the cytokine interleukin-17(IL-17) in neurological diseases. It examines the complex contributions of IL-17 to both neurodevelopmental and neurodegenerative disorders, highlighting its diverse mechanisms and its impact on neuro-immune crosstalk. Moreover, we assess the evidence supporting the potential therapeutic role of modulating IL-17, considering its beneficial and detrimental effects. Through a comprehensive analysis of current research, we aim to provide insights into the modulatory role of IL-17 in neurological disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.