ArticleFrontiers in integrative neuroscience2025
Effect of medication on the rostrolateral prefrontal oxygenation and thalamic volume asymmetry in youths with ADHD.
Article in Frontiers in integrative neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
Introduction: Symptoms of attention-deficit/hyperactivity disorder (ADHD) are closely associated with impaired executive function. Medication is the first-line treatment for ADHD, yet its effects on brain function and structure remain unclear. To investigate medication-related brain alterations in children with ADHD, we used functional near-infrared spectroscopy, which captures cortical hemodynamic activity, and structural magnetic resonance imaging, which measures subcortical volume. Methods: We investigated the differences in brain hemodynamic activity between 23 children with ADHD taking medication and 22 children who were not taking medication. Results: Compared with the medicated ADHD group, the unmedicated ADHD group showed significantly reduced activation in the left rostrolateral prefrontal cortex (channel 9, Discussion: These findings suggest that increased prefrontal activation and reduced thalamic asymmetry may reflect medication-related improvements in inhibitory control in children with ADHD.
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