ReviewFrontiers in endocrinology2025
Deciphering the role of reactive oxygen species in idiopathic asthenozoospermia.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Diagnostic classification and medical decision of idiopathic asthenozoospermia based on metabolomics analysis of seminal plasma.Journal of endocrinological investigation · 2026Article
- Melatonin Improves Sperm Quality in Asthenozoospermic Men by Preserving Acrosome Integrity, Reducing Inflammation, and Regulating Apoptosis-Related Genes and Proteins during Freeze-Thawing.International journal of fertility & sterility · 2026Article
- Efficacy and safety of oral pentoxifylline on semen parameters and reproductive hormones in idiopathic male infertility: a systematic review and meta-analysis.Translational andrology and urology · 2026Article
- Reactive Oxygen Species-Induced Damage in Cryopreserved Bovine Sperm: Mitigation Strategies.Veterinary medicine and science · 2026Review
- Reactive Oxygen and Nitrogen Species in Male Reproductive Health: From Molecular Mechanisms to Clinical Consequences.Antioxidants (Basel, Switzerland) · 2026Review
- The influence of rosmarinic acid on male reproductive health: Biological mechanisms and clinical prospects.Biochemistry and biophysics reports · 2026Review
- Epididymal transcriptional networks underlying sperm motility differences in Chinese indigenous chicken breeds.BMC genomics · 2026Article
- Enhancement of pooled chilled semen quality in four Kintamani dogs through extenders enriched with different concentrations ofJournal of advanced veterinary and animal research · 2026Article
- Spermatozoa Proteins Involved in ROS Generation and Antioxidant Defense Are Differentially Acetylated in Idiopathic Infertility.Antioxidants (Basel, Switzerland) · 2025Article
- ROS homeostasis in cell fate, pathophysiology, and therapeutic interventions.Molecular biomedicine · 2025Review
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthenozoospermia is a severe condition characterized by abnormal sperm motility, contributing to 50% of male infertility cases. Idiopathic asthenozoospermia refers to a form of this condition with no identifiable causes through routine clinical examinations, potentially linked to apoptosis and oxidative stress induced by excessive reactive oxygen species (ROS). At low concentrations, ROS positively influence physiological processes, including sperm mature and motility. However, elevated ROS levels can harm human spermatozoa through oxidative stress, primarily due to the absence of effective DNA damage repair mechanisms and inadequate antioxidant defenses. In this review, we summarize the physiological and pathophysiological roles, endogenous and exogenous sources, and therapeutic strategies related to ROS in idiopathic asthenozoospermia. Ultimately, maintaining a proper balance between ROS concentrations and antioxidants is crucial for ensuring male reproductive health.
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Registered trials
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