Evidence map›Paper›PMID 40469424›Full record

ArticleJournal of cardiology cases2025

A rare case of cytomegalovirus myocarditis complicating rejection after heart transplantation: Case report and review of literature.

Raffaele Abete, Attilio Iacovoni, Claudia Vittori, Roberta Sebastiani, Elisabetta Candiago, Andrea Gianatti, Amedeo Terzi, Michele Senni

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiology cases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raffaele AbeteDepartment of Transplant Surgery and Surgical Treatment of Heart Failure, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Attilio IacovoniDepartment of Transplant Surgery and Surgical Treatment of Heart Failure, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Claudia VittoriDepartment of Transplant Surgery and Surgical Treatment of Heart Failure, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Roberta SebastianiDepartment of Transplant Surgery and Surgical Treatment of Heart Failure, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Elisabetta CandiagoDepartment of Pathology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Andrea GianattiDepartment of Pathology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Amedeo TerziDepartment of Transplant Surgery and Surgical Treatment of Heart Failure, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Michele SenniDepartment of Cardiology, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 49-year-old female with terminal hypertrophic cardiomyopathy underwent orthotopic heart transplantation. The patient developed early acute rejection. Intensifying therapy led to improvement, but cytomegalovirus (CMV) myocarditis emerged. Aggressive management, including high-dose ganciclovir and intravenous immunoglobulin, resulted in negativization of CMV and rejection markers. Cardiac function recovered, emphasizing the challenges and successful multidisciplinary approach in managing complex post-transplant complications. Learning objectives: To diagnose and treat complications in heart transplantation, such as opportunistic infections and cellular and/or antibody-mediated rejection. To underline role of endomyocardial biopsy in heart transplant monitoring.

Indexed as

Antibody-mediated rejectionCellular rejectionCytomegalovirus myocarditisHeart transplantIntravenous immunoglobulins

Identifiers

PMID40469424
PMCPMC12130828

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.