Evidence map›Paper›PMID 40469417›Full record

ArticleEJHaem2025

Nivolumab Induces Durable Remission in Relapsed/Refractory ALK-Negative ALCL After Allogeneic Blood Stem Cell Transplantation-A Case Report and Literature Review.

Ben-Niklas Baermann, Kathrin Nachtkamp, Paul Jäger, Paula Kessler, Emil Novruzov, Frederik L Giesel, Helena Peters, Maximilian Seidl, Mark Uhlenbruch, Sascha Dietrich and 1 more

Abstract read
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ben-Niklas BaermannDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf Düsseldorf Germany.ORCID https://orcid.org/0009-0000-1699-9478
Kathrin NachtkampDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf Düsseldorf Germany.
Paul JägerDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf Düsseldorf Germany.ORCID https://orcid.org/0000-0001-9250-2064
Paula KesslerDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf Düsseldorf Germany.
Emil NovruzovCenter for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf Düsseldorf Germany.
Frederik L GieselCenter for Integrated Oncology Aachen-Bonn-Cologne-Düsseldorf Düsseldorf Germany.
Helena PetersDepartment of Diagnostic and Interventional Radiology Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf Düsseldorf Germany.
Maximilian SeidlInstitute of Pathology University Hospital Düsseldorf Düsseldorf Germany.
Mark UhlenbruchDepartment of Pneumology Cardiology and Intensive Care Medicine Florence-Nightingale Hospital Düsseldorf Germany.
Sascha DietrichDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf Düsseldorf Germany.
Guido KobbeDepartment of Hematology Oncology and Clinical Immunology Medical Faculty and University Hospital Duesseldorf, Heinrich-Heine-University Duesseldorf Düsseldorf Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Relapsed or refractory anaplastic large cell lymphoma (r/r-ALCL) remains an important therapeutic challenge, especially after allogeneic stem cell transplantation (alloHSCT). Due to encouraging results in other lymphoid diseases, PD-1 blockade was investigated in T-cell lymphoma in a small number of patients, but short duration of remission and significant adverse events were observed. Case Report: Here, we report successful and durable remission induction for more than 2 years with nivolumab for r/r-ALCL even without any evidence of PD-L1 expression. Conclusion: This report and literature review emphasizes the importance of the graft-versus-lymphoma effect and its potential pharmacological stimulators in the field of lymphoma treatment.

Indexed as

case reportGVHDstem cell transplantationT‐cell lymphoma

Identifiers

PMID40469417
PMCPMC12136181

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.