ArticleSurgical neurology international2025
Novel untethered micro-robotic platform developed for minimally invasive ultra-selective microsurgical procedures and targeted drug delivery: Preliminary characterization of tissue response to intraparenchymal navigation in ovine brain.
Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Background: To expand surgical options for safe, minimally invasive microsurgical procedures or targeted delivery of diverse therapeutics, a novel untethered micro-robotic platform is presented. This technology enables precision travel to predetermined central nervous system (CNS) parenchymal and complex cerebrospinal fluid pathway targets. Methods: Utilizing an Results: No deaths or surgical complications occurred in either group. No neurological or behavioral differences were identified between the groups. No significant differences in gross or microscopic tissue pathology were identified when comparing the channels created by the micro-robot to the catheter control group. Conclusion: These findings support the equivalence of tissue responses to this micro-robot navigation compared to catheter insertion as a preliminary surrogate for addressing the safety and accuracy of this novel platform. This platform may set a new standard for safe, anatomically precise, and minimally invasive therapeutic procedures. The described approach offers untethered navigation, capable of traversing CNS tissues in controlled, complex, curvilinear trajectories. Preliminary results utilizing this micro-robotic capacity to deliver diverse therapeutic payloads are discussed. Novel applications designed to address CNS pathologies, including neurodegenerative diseases, epilepsy, neuro-oncology, and functional and microsurgical procedures, are proposed.
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