ReviewFrontiers in immunology2025
Dysregulated immune cell responses in severe dengue pathogenesis.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Therapeutic approaches against dengue virus: current status of vaccines, antivirals, and monoclonal antibodies.Emerging microbes & infections · 2026Review
- Unresolved questions in pediatric dengue: from disease mechanisms to prevention.Current opinion in infectious diseases · 2026Review
- Bulk transcriptomics of peripheral blood mononuclear cells delineates systems-level immune dysregulation in pediatric dengue infection.NPJ systems biology and applications · 2026Article
- The Role of Natural Killer (NK) Cells in Dengue Virus Infection: A Narrative Review.Health science reports · 2026Article
- Efficacy of Probiotics and Postbiotics in Treating Dengue Fever - A Potential Strategy to Reduce Antibody-dependent Enhancement.Probiotics and antimicrobial proteins · 2026Review
- Article
- Dual Infection with dengue virus and infective endocarditis leading to brain abscess, multiorgan infarctions, and horner syndrome: a case report with literature review.BMC cardiovascular disorders · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Life-threatening severe dengue (SD) develops in a small subset of patients suffering from dengue fever (DF), a febrile disease that develops following infection with dengue virus (DENV). DENV is a mosquito-borne positive -sense RNA virus. The rapid spread of DENV vectors, which was exacerbated by climate change and inadequate control measures, has led to outbreaks affecting millions worldwide. There is no specific treatment for DF, and the recently introduced vaccines are ineffective in containing the current outbreaks. Like many other viral diseases, the immune system plays a key role in dengue pathogenesis. The lack of models replicating the disease's immunopathological features has hampered the understanding of the immune system's role in developing this disease. Recent advances, such as single-cell approaches, provide better systems and methodologies to study the role of different immune cells in SD, closing this gap and providing a better mechanistic understanding of disease pathogenesis and promoting the identification of targets for therapeutic interventions. Here, we summarize recent advances in SD research, focusing on immune cell interactions and their role in disease severity.
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Registered trials
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