Evidence map›Paper›PMID 40469291›Full record

ArticleFrontiers in immunology2025

Osteoclast-like multinucleated giant cells reinforce polycaprolactone grafts.

Halldór Bjarki Einarsson, Anders Frisk Mortensen, Morten Schallburg Nielsen, Menglin Chen, Søren Roesgaard Nielsen, David Christian Evar Kraft, Jonas Jensen, Mette Bjerre, Morten Nørregaard Andersen, Jens Vinge Nygaard and 2 more

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Halldór Bjarki EinarssonDepartment of Neurosurgery, Aalborg University Hospital, Aalborg, Denmark.
Anders Frisk MortensenDepartment of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.
Morten Schallburg NielsenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Menglin ChenDepartment of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.
Søren Roesgaard NielsenInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Aarhus, Denmark.
David Christian Evar KraftDepartment of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.
Jonas JensenDepartment of Neuroradiology, Aarhus University Hospital, Aarhus, Denmark.
Mette BjerreDepartment of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Morten Nørregaard AndersenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Jens Vinge NygaardDepartment of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.
Cody Eric BüngerDepartment of Orthopaedic Surgery, Aarhus University Hospital, Aarhus, Denmark.
Thomas Vorup-JensenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Successful application of advanced engineered materials in osteoplasty requires a biological understanding of the recipient reaction. The immune system acts like a double-edged sword by maintaining targeted tissue and rejecting grafts. Nevertheless, even for promising graft materials such as polycaprolactone, insights on contact with immune cells have been restricted due to lacking quantitative assays. Here, we show that polycaprolactone graft sites after cranioplasty are dominated by an immature type of multinucleated giant cells, probably derived from transmigrating peripheral monocytes. The cells interact with the polycaprolactone through extensive pseudopodia formation and localized polymer dissolution. Dynamic mechanical analysis revealed osteoclast-like cells, derived

Indexed as

Giant CellsOsteoclastsPolyestersCells, CulturedHumansMaleMonocytespolycaprolactonePolyestersdynamic mechanical analysisintegrinsmonocytemultinucleated giant cellspolycaprolactone implants

Identifiers

PMID40469291
PMCPMC12133856

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.