Evidence map›Paper›PMID 40469283›Full record

ArticleFrontiers in immunology2025

Spatial immune profiling reveals distinct microenvironments in medullary thyroid carcinoma.

Maria Eduarda de Castro, Gustavo Forlin de Siqueira, Jean Ferrante Mariano, Marina Malta Letro Kizys, Lucieli Ceolin, Fernando Augusto Soares, Rodrigo Natal, Humberto Carneiro, Rodrigo Nalio Ramos, Laura Sterian Ward and 9 more

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Maria Eduarda de CastroLaboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Gustavo Forlin de SiqueiraLaboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Jean Ferrante MarianoLaboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Marina Malta Letro KizysLaboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Lucieli CeolinLaboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Fernando Augusto SoaresPathology Division, D'Or Research Institute, Rede D'Or Hospitals Network, São Paulo, Brazil.
Rodrigo NatalPathology Division, D'Or Research Institute, Rede D'Or Hospitals Network, São Paulo, Brazil.
Humberto CarneiroPathology Division, D'Or Research Institute, Rede D'Or Hospitals Network, São Paulo, Brazil.
Rodrigo Nalio RamosPathology Division, D'Or Research Institute, Rede D'Or Hospitals Network, São Paulo, Brazil.
Laura Sterian WardLaboratory of Cancer Molecular Genetics, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Niels Olsen Saraiva CamaraDepartment of Immunology, Institute of Biomedical Sciences, University of São Paulo, (USP), São Paulo, Brazil.
Cleber Pinto CamachoLaboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Flavia de Oliveira Facuri ValenteLaboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Susan Chow LindseyLaboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Diego Dias Dos SantosDepartment of Morphology and Genetics, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), SP, São Paulo, Brazil.
Cristiane Damas GilDepartment of Morphology and Genetics, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), SP, São Paulo, Brazil.
João Roberto Maciel MartinsLaboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Rui Monteiro de Barros MacielLaboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Lucas Leite CunhaLaboratory of Molecular and Translational Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Medullary thyroid carcinoma (MTC) is a rare and aggressive thyroid cancer with a challenging prognosis. While the immune microenvironment plays a crucial role in cancer progression, its role in MTC remains underexplored compared to more common thyroid cancers. Methods: this study investigates the immune landscape of MTC by systematically evaluating immune cell infiltration and expression of immune markers across various tissue topographies. We utilized advanced immunohistochemical techniques to analyze tissue samples from 24 MTC patients, focusing on the tumor core, interface with healthy tissue, adjacent normal thyroid tissue, and lymph node metastases. Results: our findings reveal a distinct immune profile with increased CD3+, CD4+, CD8+ and CD20+ lymphocytes in normal tissues adjacent to tumors and a notable presence of granzyme B+ cells in the tumor interface, particularly in patients with structural disease. Additionally, we observed a significant enrichment of mast cells in metastatic tissues. Discussion: these results highlight the complex and spatially dependent immune landscape of MTC, suggesting implications for targeted immunotherapy. This study provides novel insights into the immune microenvironment of MTC and emphasizes the need for further research to elucidate its impact on disease progression and therapeutic response.

Indexed as

Carcinoma, NeuroendocrineLymphocytes, Tumor-InfiltratingThyroid NeoplasmsTumor MicroenvironmentAdultAgedBiomarkers, TumorFemaleHumansLymphatic MetastasisMaleMiddle AgedBiomarkers, Tumorimmune microenvironmentmast cellsmedullary thyroid carcinoma (MTC)PD-L1 expressiontumor-infiltrating lymphocytes (TILs)

Identifiers

PMID40469283
PMCPMC12133767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.