ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Ultra-rare variants in LAMA2 are risk factors for frontotemporal dementia and motor neuron disease.Human molecular genetics · 2026Article
- Glycosphingolipids in Dementia: Insights from Mass Spectrometry and Systems Biology Approaches.Biomedicines · 2025Review
- The Serum Lipid Profile of Relapsing Multiple Sclerosis Differs Reproducibly From Healthy Controls.Journal of neurochemistry · 2025Article
- Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionBlood biomarkers are needed to facilitate new therapeutic trials and improve management of behavioral variant frontotemporal dementia (bvFTD). Since altered white matter integrity is characteristic of bvFTD, this study aimed to determine if plasma levels of myelin-enriched glycolipids are altered in bvFTD and correlate with white matter integrity.
methodsNineteen glycolipids were quantified in bvFTD (
resultsEleven lipids were significantly lower in bvFTD compared to control subjects, and seven were inversely correlated with disease duration, with C22:0 hexosylceramide most strongly correlated. FDC was lower in frontotemporal white matter tracts of bvFTD compared to control subjects, and plasma C22:0 hexosylceramide was significantly correlated with FDC of these tracts in bvFTD but not control subjects. DISCUSSION: Circulating glycolipids may be a valuable biomarker of myelin integrity and disease progression in FTD. Highlights: Blood biomarkers are needed for behavioral variant frontotemporal dementia (bvFTD).Plasma hexosylceramides are reduced in bvFTD cases compared with normal controls.Plasma hexosylceramides correlate with disease duration in bvFTD.Plasma hexosylceramides correlate with brain white matter integrity in bvFTD.Plasma glycolipids have potential as biomarkers of disease progression in bvFTD.
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