ArticleJHLT open2025
Trans-atrial Inflow Cannula Configuration for Durable HeartWare Left Ventricular Assist Device in Hypertrophic Cardiomyopathy: A Case Series and a Word of Caution.
Article in JHLT open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Left Atrial Inflow Ventricular Assist Device Utilization in Patients With Small or Restrictive Left Ventricles: A Systematic Review.Artificial organs · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/objectives: Implantation of a durable left ventricular assist device (LVAD) in patients with hypertrophic cardiomyopathy (HCM) is technically challenging. We describe our experience using a trans-atrial inflow cannulation and a left atrial-to-aorta (LA-Ao) LVAD configuration. Pump hemodynamics, selection criteria, technical considerations, and postoperative management reflections are discussed. Methods: Three patients who underwent centrifugal pump implantation using LA-Ao configuration between January 2019 and May 2021 at our institution were reviewed. Patient characteristics, hemodynamics, pump parameters, outcomes are presented. Results: All patients (2 males, 1 female, aged: 40-64 years-old) had end-stage heart failure secondary to HCM and were INTERMACS Profile 3. Two patients were successfully bridged to transplantation after four months of support, and one patient died from pump thrombosis and stroke. Compared with the left ventricle-to aorta (LV-Ao) confirmation, the variations of the pump flow through the cardiac cycle are inversed in the LA-Ao configuration, and the pressure head is higher leading to a reduced pump-flow at a fixed pump speed. The presence of severe bi-atrial enlargement is an important selection criterion. Conclusion: LA-Ao LVAD configuration might be an alternative for durable LVAD implantation in highly selected candidates with small left ventricular cavity. Post-operative management should account for the higher risk of pump thrombosis related to a reduced trans-pump flow in this configuration.
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