ArticleClinical medicine insights. Endocrinology and diabetes2025
Subclinical Hypothyroidism in Polycystic Ovary Syndrome: Prevalence and Impact on Metabolic and Cardiovascular risk.
Article in Clinical medicine insights. Endocrinology and diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The impact of subclinical hypothyroidism on core reproductive hormones and ovarian endocrine status in patients with polycystic ovary syndrome: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Correlation between thyroid hormone levels and cognitive dysfunction in older patients with subclinical hypothyroidism : A matched groups retrospective study.Wiener klinische Wochenschrift · 2026Article
- Comparison of glucolipid metabolic profile, thyroid hormone levels, and reproductive endocrine function in polycystic ovary syndrome patients with/without metabolic syndrome.American journal of translational research · 2026Article
- Chronic inflammatory activity in women with normogonadotropic anovulation complicated by subclinical thyroid dysfunction: a prospective cohort study.Frontiers in endocrinology · 2026Article
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Authors and funding
8 authors.
Funding
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Abstract
Background: Polycystic ovary syndrome (PCOS) is a complex condition linked to long-term health risks such as cardiovascular disease, type 2 diabetes, and metabolic syndrome. Subclinical hypothyroidism (SCH) shares overlapping symptoms with PCOS, but their relationship remains debated. SCH prevalence in PCOS patients and its impact on cardiovascular and metabolic health is debated and thus warrants further research. This research examined the association between SCH and PCOS in a Tunisian clinical-based population. Methods: We conducted a prospective cross-sectional study of 161 PCOS patients and 75 age-matched controls recruited from 2023 to 2024. All participants underwent thyroid function testing, metabolic profiling, and hormonal assays. Statistical analyses included Mann-Whitney Results: Among 236 participants (161 PCOS, 75 controls), SCH prevalence was higher in PCOS patients (14.9%) compared to controls (5.3%, Conclusion: SCH is more prevalent in PCOS and may worsen insulin resistance and dyslipidemia. Addressing thyroid dysfunction in PCOS patients may be beneficial for more effective management strategies, ultimately improving reproductive, metabolic, and cardiovascular outcomes for affected women.
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