Evidence map›Paper›PMID 40469214›Full record

ReviewThe World Allergy Organization journal2025

ARIA-Italy multidisciplinary consensus on nasal polyposis and biological treatments: Update 2025.

Carlo Lombardi, Rikki F Canevari, Diego Bagnasco, Maria Beatrice Bilò, Giorgio Walter Canonica, Cristiano Caruso, Paolo Castelnuovo, Lorenzo Cecchi, Orietta Calcinoni, Mauro Carone and 34 more

Abstract readReview
In one paragraph

Review in The World Allergy Organization journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

44 authors.

Carlo LombardiUnit of Allergology, Clinical Immunology & Respiratory Diseases, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy.
Rikki F CanevariDipartimento DISC, Clinica Otorinolaringoiatria, IRCCS Policlinico San Martino, Università di Genova, Italy.
Diego BagnascoAllergy and Respiratory Diseases, IRCCS PoliclinicoS.Martino, University of Genoa, Italy.
Maria Beatrice BilòDipartimento di Scienze Cliniche e Molecolari (DISCLIMO), Università Politecnica delle Marche, Azienda Ospedaliero-Universitaria delle Marche, Ancona, Italy.
Giorgio Walter CanonicaDepartment of Biomedical Science-Humanitas University-Pieve Emanuele (MI), Personalized Medicine, Asthma and Allergy-IRCCS Humanitas Research Hospital-Rozzano (NI), Italy.
Cristiano CarusoUOSD DH Internal Medicine and Digestive Diseases, Fondazione Policlinico A. Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome Italy.
Paolo CastelnuovoDBSV, Clinica ORL, Università Insubria, ASST-Settelaghi, Varese, Italy.
Lorenzo CecchiSOS Allergologia e Immunologia Clinica Prato, USL Toscana Centro, Italy.
Orietta CalcinoniSocietà Italiana Liberi Professionisti, Centro Medico Turati, Milan, Italy.
Mauro CaroneIstituti Clinici Scientifici Maugeri, IRCCS Bari, UOC di Pneumologia, Bari, Italy.
Marco CassatellaSocietà Italiana di Immunologia Clinica e Allergologia.PatologIa Generale, University of Italy, Italy.
Renato CutreraPediatric Pulmonology and Cystic Fibrosis Unit Respiratory Intermediate Care Unit, Sleep and Long Term Ventilation Unit, ERN - Lung Reference Center for Rare Respiratory diseases Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Gianni DanesiUnitàOperativa di Otorinolaringoiatria e Microchirurgia della Base Cranica, Ospedale Papa Giovanni XXIII, Bergamo, Italy.
Eugenio De CorsoOtorhinolaryngology Unit, A. Gemelli University Hospital IRCCS, Rome, Italy.
Mario Di GioacchinoSocietà Italiana di Asma Allergologia e Immunologia Clinica, University of Chieti, Italy.
Fabiano Di MarcoDipartimento di Scienze della Salute, Università degli Studi di Milano, ASST Papa Giovanni XXIII, Bergamo, Italy.
Stefania GalloOspedale di Circolo e Fondazione Macchi, Varese, Italy.
Matteo GelardiORL Clinic, University of Foggia, Italy.
Enrico HefflerDepartment of Biomedical Science-Humanitas University-Pieve Emanuele (MI), Personalized Medicine, Asthma and Allergy-IRCCS Humanitas Research Hospital-Rozzano (NI), Italy.
Clara ImperatoreAICNA, Asl Napoli 1 Centro Distretto 24 L. Crispi, Italy.
Cristiana IndolfiDipartimento della Donna, del Bambino e di Chirurgia Generale e Specialistica, Università degli Studi della Campania "Luigi Vanvitelli" Italy.
Massimo LandiDepartment of Medical Sciences - Graduate School of Allergology and Clinical Immunology University of Turin, Italy.
Amelia LicariSC Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Francesco LiottaDipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Italy.
Alberto MacchiDBSV, Clinica ORL, Università Insubria, ASST-Settelaghi, Varese, Italy.
Luca MalvezziOtorinolaringoiatria e Chirurgia Cervico Facciale - Humanitas San Pio X Ambulatorio II Livello Rino-Allergologico IRCCS HumanitasResearch Hospital, Italy.
Sara MantiMedico Chirurgo, Pediatra, Dottore di Ricerca, Ricercatore Tempo Determinato UOC Pediatria, AOU G. Martino, Università di Messina, Italy.
Francesco MenzellaUOC Pneumologia Distretto di Asolo, AULSS2 Marca Trevigiana, Italy.
Claudio MichelettoUOC di Pneumologia, Azienda Ospedaliera Universitaria Verona, Veneto, Italy.
Fabio MidullaDipartimento Materno Infantile e Scienze Urologiche Policlinico Umberto I, Roma, Italy.
Michele Miraglia Del GiudiceDepartment of Medical Sciences - Graduate School of Allergology and Clinical Immunology University of Turin, Italy.
Antonino MusarraServizio di Allergologia, Casa della Salute di Scilla, ASP di Reggio Calabria, Italy.
Vincenzo PatellaUOC di Medicina Interna Ospedale Civile "Santa Maria della Speranza", Salerno, Italy.
Diego PeroniDepartment of Clinical and Experimental Medicine, University of Pisa, Italy.
Laura PetrarcaDepartment of Maternal Infantile and Urological Science, Università"La Sapienza, Roma, Italy.
Giorgio PiacentiniUOC di Pediatria, AOUI Verona, Dipartimento di Scienze Chirurgiche, Odontostomatologiche e Materno-Infantili, Università di Verona, Italy.
Alessandro PusateriUOC Otorinolaringoiatria ASST Papa Giovanni XXIII Bergamo, Italy.
Veronica SecciaASP 6, Palermo, Italy.
Gianenrico SennaDepartment of Medicine, Asthma Center, University of Verona, Italy.
Adriano VaghiASST RodhensePneumologia, Italy.
Carlo VancheriUOC Malattiedell'ApparatoRespiratorio, Università degli Studi di Catania, Italy.
Giovanni PassalacquaAllergy and Respiratory Diseases, IRCCS PoliclinicoS.Martino, University of Genoa, Italy.
ARIA Italy
ARIA-ITALY PANEL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, it was recognized that type-2 inflammation connects nasal polyposis and severe asthma (SA) in addition to other type-2 diseases. Thus, some biological drugs developed for SA appeared to exert a favourable effect also in nasal polyposis. So far, there are several trials supporting this concept; therefore, some monoclonal antibodies already used for SA were assessed also in chronic rhinosinusistis with nasal polyposis (CRSwNP), with promising results. Since different specialists are involved in the management of nasal polyposis (eg, pulmonologists, ENT specialists, allergists, immunologists, pediatricians), it was felt that an updated educational and informative document was needed to better identify the indications of biological therapies in nasal polyposis. We collected the main Italian scientific societies, and prepared (under the umbrella of Allergic Rhinitis and its Impact on Asthma, ARIA) a document endorsed by all societies, to provide a provisional statement for the future use of monoclonal antibodies (MAbs) as a medical treatment for polyposis, possibly associated with SA. The above mentioned document was the first endorsed document on this aspect, and the additional evidence required an update. The current pathogenic knowledge and the experimental evidence are herein reviewed, and some suggestions for a correct prescription and follow-up are provided.

Indexed as

ARIA (allergic rhinitis and its impact on asthma)Biological agentsChronic rhinosinusitis with nasal polyposisMonoclonal antibodiesPersonalized medicineSevere asthma

Identifiers

PMID40469214
PMCPMC12136883

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.