Evidence map›Paper›PMID 40469114›Full record

ArticleiScience2025

Postnatal hyperosmolality alters development of hypothalamic feeding circuits with context-specific changes in ingestive behavior.

Serena R Sweet, Jessica E Biddinger, Jessie B Zimmermann, Gina L Yu, Richard B Simerly

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Serena R SweetDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Jessica E BiddingerDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Jessie B ZimmermannDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Gina L YuDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
Richard B SimerlyDepartment of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN 37232, USA.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Leptin and Developmental Programming of Hypothalamic Autonomic OutflowR01DK106476 · NIDDK · VANDERBILT UNIVERSITY · PI SIMERLY, RICHARD B · 2016 to 2024
$3.7M
Developmental programming of neural circuits integrating drinking and feedingF31HD106890 · NICHD · VANDERBILT UNIVERSITY · PI SWEET, SERENA · 2022 to 2024
$95k
NICHD NIH HHS F31 HD106890NICHD NIH HHS P50 HD103537NIDDK NIH HHS R01 DK106476
6 · The paper itself

Abstract

Drinking and feeding are tightly coordinated homeostatic events and the paraventricular nucleus of the hypothalamus (PVH) represents a possible node of neural integration for signals related to energy and fluid homeostasis. We used

Indexed as

Developmental biologyDevelopmental neuroscienceNeuroscience

Identifiers

PMID40469114
PMCPMC12136832

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.