Evidence map›Paper›PMID 40469030›Full record

ArticleJournal of neurochemistry2025

Exploring Iron Deposition Patterns Using Light and Electron Microscopy in the Mouse Brain Across Aging and Alzheimer's Disease Pathology Conditions.

Victor Lau, Jared VanderZwaag, Colin J Murray, Marie-Ève Tremblay

Abstract read
In one paragraph

Article in Journal of neurochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Programmed cell death: a promising management for Alzheimer's disease.Apoptosis : an international journal on programmed cell death · 2026
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Victor LauDivision of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID https://orcid.org/0000-0003-1147-2073
Jared VanderZwaagDivision of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID https://orcid.org/0000-0002-1546-0304
Colin J MurrayDivision of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID https://orcid.org/0009-0008-2307-3460
Marie-Ève TremblayDivision of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.ORCID https://orcid.org/0000-0003-2863-9626

Funding

Innovation John R. Evans Leaders Fund 39965
6 · The paper itself

Abstract

Alzheimer's disease (AD) involves cognitive decline, possibly via multiple concurrent pathologies associated with iron accumulation. To investigate if iron accumulation in AD is more likely due to pathological iron-rich compartments, or a compensatory response of iron within oligodendrocytes to disease progression, we sought to quantify iron-rich staining (via Perl's diaminobenzidine; DAB). Healthy wild-type (WT) and APP

Indexed as

AgingAlzheimer DiseaseBrainIronAnimalsMaleMiceMice, Inbred C57BLMice, TransgenicMicroscopy, ElectronPlaque, AmyloidIronAlzheimer's diseaseamyloid plaquesCNS border‐associated cellselectron microscopyiron depositionmicroglia

Identifiers

PMID40469030
PMCPMC12138743

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.