Evidence map›Paper›PMID 40469000›Full record

ArticleEndocrinology2025

Neuromedin U Deficiency Disrupts Daily Testosterone Fluctuation and Reduces Wheel-Running Activity in Rats.

Mai Otsuka, Yu Takeuchi, Maho Moriyama, Sakura Egoshi, Yuki Goto, Tingting Gu, Atsushi P Kimura, Shogo Haraguchi, Taishi Yoshii, Sakae Takeuchi and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mai OtsukaGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Yu TakeuchiGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Maho MoriyamaGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Sakura EgoshiDepartment of Biology, Faculty of Science, Okayama University, Okayama 700-8530, Japan.
Yuki GotoGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Tingting GuGraduate School of Environmental, Life, Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Atsushi P KimuraDepartment of Biological Sciences, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan.
Shogo HaraguchiDepartment of Biochemistry, Showa University School of Medicine, Tokyo 142-8555, Japan.
Taishi YoshiiGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Sakae TakeuchiGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Makoto MatsuyamaDivision of Molecular Genetics, Shigei Medical Research Institute, Okayama 701-0202, Japan.ORCID 0000-0003-2606-059X
George E BentleyDepartment of Integrative Biology and Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA 94720, USA.
Sayaka AizawaGraduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.ORCID 0000-0002-5731-8410

Funding

KAKENHI 24K09533Okayama University
6 · The paper itself

Abstract

The objective of this study was to elucidate the role of endogenous Neuromedin U (NMU) in rats by performing NMU knockout (KO). Male, but not female NMU KO rats exhibited decreased wheel-running activity vs wildtype (WT), although overall home cage activity was not affected. Plasma testosterone in WT rats varied significantly over the course of a day, with a peak at ZT1 and a nadir at ZT18, whereas in NMU KO rats testosterone remained stable throughout the day. Chronic administration of testosterone restored wheel-running activity in NMU KO rats to the same level as in WT rats, suggesting that the decrease in wheel-running activity in NMU KO rats is due to the disruption of the diurnal change of testosterone. Accordingly, expression of the luteinizing hormone beta subunit (Lhb) mRNA in the pars distalis of anterior pituitary was significantly lower in NMU KO rats; immunostaining revealed that the size of luteinizing hormone (LH)-expressing cells was also relatively small in those animals. In the brain of male WT rats, Nmu was highly expressed in the pars tuberalis, and the NMU receptor Nmur2 was highly expressed in the ependymal cell layer of the third ventricle. This study reveals a novel function of NMU and indicates that endogenous NMU in rats plays a role in the regulation of motivated activity via regulation of testosterone.

Indexed as

Motor ActivityNeuropeptidesTestosteroneAnimalsCircadian RhythmFemaleLuteinizing HormoneMaleRatsRats, Sprague-DawleyLuteinizing Hormoneneuromedin UNeuropeptidesTestosteroneactivitymotivationNeuromedin Urattestosteronewheel-running

Identifiers

PMID40469000
PMCPMC12204324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.