ArticleThe Journal of clinical endocrinology and metabolism2025
The Role of Muscular Fitness on Bone Mineral Content and Areal Bone Mineral Density in Youth With Type 1 Diabetes.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Effects of Diactive-1-Supported Progressive Resistance Training on Body Composition in Youth With Type 1 Diabetes.Journal of cachexia, sarcopenia and muscle · 2026Trial
- The Role of Muscular Fitness on Bone Mineral Content and Areal Bone Mineral Density in Youth With Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
contextType 1 diabetes in youth increases the risk of compromised bone health due to glycemic dysregulation. Muscular fitness may play a role in improving bone health during growth.
objectiveThis study aimed to investigate the association between muscular fitness and bone health in youth with type 1 diabetes.
methodsA total of 83 young individuals with type 1 diabetes (aged 6-18 years; 44.6% girls) from the Diactive-1 cohort study were followed for 2 years. Dual-energy x-ray absorptiometry whole-body scans were used to assess bone mineral content (BMC) and areal bone mineral density (aBMD) of the total body less head (TBLH), arms, legs, pelvis, and spine. Muscular fitness (handgrip strength, 1 repetition maximum, and muscle power) was assessed with a dynamometer and eGYM devices. Handgrip strength and TBLH bone parameters were age- and sex-standardized using the FitBack Project and BMD Childhood Study, respectively.
resultsLinear mixed models showed longitudinal associations of handgrip strength with TBLH-BMC (unstandardized beta coefficient [B] = 17.18, 95% confidence interval [CI] 12.47-21.90) and TBLH-aBMD (B = 0.004, 95% CI 0.002-0.006); RM with TBLH-BMC (B = 20.09, 95% CI 10.88-29.31) and TBLH-aBMD (B = 0.007, 95% CI 0.004-0.011); and power with TBLH-BMC (B = 26.80, 95% CI: 17.31-36.28) and TBLH-aBMD (B = 0.009, 95% CI 0.005-0.012). Comparable results were observed across the other regions (P < .05). Additionally, analyses with standardized data confirmed the relationships of handgrip z-scores with TBLH-BMC z-scores (B = 0.19, 95% CI 0.08-0.30) and TBLH-aBMD z-scores (B = 0.350, 95% CI: 0.210-0.490).
conclusionIn pediatric patients with type 1 diabetes, higher muscular fitness could serve as a complementary therapeutic strategy to preserve or enhance bone health.
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