Evidence map›Paper›PMID 40468935›Full record

ReviewMini reviews in medicinal chemistry2025

Natural Hydrazone Derivatives: Their Sources, Structures, and Bioactivities.

Hagar M Mohamed, Hazem G A Hussein, Gamal A Mohamed, Shaimaa G A Mohamed, Sabrin R M Ibrahim

Abstract readReview
In one paragraph

Review in Mini reviews in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hagar M MohamedDepartment of Medical Laboratory Analysis, College of Medical & Health Sciences, Liwa University, Abu Dhabi 41009, United Arab of Emirates.ORCID 0000-0002-6553-7840
Hazem G A HusseinGeneral Medicine Practice Program, Batterjee Medical College, Jeddah, 21442, Saudi Arabia.ORCID 0009-0008-2233-6695
Gamal A MohamedDepartment of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.ORCID 0000-0002-2971-6008
Shaimaa G A MohamedDepartment of Fixed Prosthodontics, Faculty of Dentistry, The British University in Egypt, El Sherouk City, Suez Desert Road, Cairo, 11837, Egypt.ORCID 0000-0002-6966-2323
Sabrin R M IbrahimDepartment of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah, 21442, Saudi Arabia.ORCID 0000-0002-6858-7560

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrazone-containing compounds are a diverse group of bioactive compounds known for their unique chemical features and diverse biological activities. Natural hydrazone derivatives have been identified from various natural sources, including bacteria, plants, fungi, and marine organisms. This work provides a comprehensive review of published works on natural hydrazone derivatives, including their sources, structural features, and biological activity in the period from 1967 to March 2025. In this work, 72 compounds were reviewed, along with 75 references being cited. The reported findings in this work highlight the therapeutic potential of these compounds in pharmaceutical research and drug discovery.

Indexed as

Biological ProductsHydrazonesAnimalsAntineoplastic AgentsBacteriaDrug DiscoveryFungiHumansMolecular StructureAntineoplastic AgentsBiological ProductsHydrazonesbioactivitiesdrug discoveryelectrophilic.Hydrazone derivativesion sensingnitrogen boost

Identifiers

PMID40468935
PMCPMC13266690

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.