ArticleDiabetes, obesity & metabolism2025
Genetic risk and polygenic risk score assessment of prediabetes and progression to type 2 diabetes.
Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Refining the Genetic Contribution to Type 2 Diabetes Subtypes.Diabetes, obesity & metabolism · 2026Article
- Genetic risk and polygenic risk score assessment of prediabetes and progression to type 2 diabetes.Diabetes, obesity & metabolism · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
aimsTo identify susceptibility loci to prediabetes and evaluate the performance of existing polygenic risk scores (PGS) for type 2 diabetes (T2D) in predicting prevalent prediabetes and progression to diabetes. MATERIALS AND
methodsWe conducted a case-control Genome-Wide Association Study (GWAS) on Qatar Biobank (QBB) participants with prediabetes (n = 2267) and normoglycaemia (n = 8665). We further evaluated the performance of 140 existing PGS for T2D in predicting prediabetes using logistic regression in the baseline QBB cohort (n = 10 932) and progression to T2D using Cox regression in the follow-up cohort (n = 2143).
resultsGWAS identified two loci associated with prediabetes (p < 5 × 10
conclusionsThis study identified two genetic loci associated with prediabetes. PGS004838 showed the highest performance in predicting prediabetes and progression to T2D, with the strongest effect reported to date. Our findings have clinical translation potential in risk stratification and early intervention.
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