Evidence map›Paper›PMID 40468841›Full record

ArticleThe International journal of eating disorders2025

Effects of Early Weight Trends on Residential Treatment Outcomes Among Adolescents With Anorexia Nervosa.

Simar Singh, Sasha Gorrell, Catherine R Drury, Alan Duffy, Philip S Mehler, Kianna Zucker, Daniel Le Grange, Erin E Reilly, Renee D Rienecke

Abstract read
In one paragraph

Article in The International journal of eating disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simar SinghDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.ORCID 0000-0002-3170-2924
Sasha GorrellDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.ORCID 0000-0002-8861-8547
Catherine R DruryDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.ORCID 0000-0002-3177-0433
Alan DuffyEating Recovery Center and Pathlight Mood & Anxiety Center, Denver, Colorado, USA.ORCID 0000-0002-8697-9285
Philip S MehlerEating Recovery Center and Pathlight Mood & Anxiety Center, Denver, Colorado, USA.ORCID 0000-0002-9598-6428
Kianna ZuckerDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.ORCID 0009-0002-8232-9098
Daniel Le GrangeDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.ORCID 0000-0001-7293-9496
Erin E ReillyDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA.ORCID 0000-0001-9269-0747
Renee D RieneckeEating Recovery Center and Pathlight Mood & Anxiety Center, Denver, Colorado, USA.ORCID 0000-0003-0423-7403

Funding

CLINICAL SERVICES RESEARCH TRAINING PROGRAMT32MH018261 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaja Zabrina LeWinn, Rachel L. Loewy · 1985 to 2026
$7.0M
Using Computational Modeling to Test Reinforcement Learning as a Predictor of Response in Family-Based Treatment for Adolescent Anorexia NervosaK23MH131871 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Erin E. Reilly · 2022 to 2026
$982k
Neural Correlates of Reinforcement Learning Specific to Hyperactivityin Adolescent Anorexia NervosaK23MH126201 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORRELL, SASHA CATHERINE · 2021 to 2025
$848k
Characterizing Acute Exercise Response in Restrictive Eating DisordersR21MH131787 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI GORRELL, SASHA CATHERINE, SCHAUMBERG, KATHERINE · 2023 to 2023
$450k
Brain and Behavior Research Foundation, Young Investigator AwardNIMH NIH HHS K23 MH126201NIMH NIH HHS K23MH126201NIMH NIH HHS K23 MH131871NIMH NIH HHS K23MH131871NIMH NIH HHS R21MH131787NIMH NIH HHS T32MH018261University of California, San Francisco John E. Cox Fund
6 · The paper itself

Abstract

backgroundWeight variability (WV), or daily-to-weekly fluctuations in weight, associates with increased eating pathology in adults with bulimia nervosa and greater weight gain across the developmental span in healthy controls, but few studies have explored these relations in adolescents with anorexia nervosa (AN). Given the importance of early weight gain during treatment for AN prognosis, WV could impact outcomes via effects on weight trends and related psychopathology. The current study examined whether WV and the slope of weight change predict eating disorder symptoms at the end of treatment (EOT) among adolescents with AN.

methodAdolescents with AN (N = 284) receiving residential treatment completed the Eating Disorder Examination Questionnaire (EDE-Q) at admission and EOT. WV was calculated using the root-mean-squared-error of daily weights over the first 14 days of treatment. Linear regressions examined the effect of WV, slope of weight change over 14 days, and their interaction on percent expected body weight (%EBW) and EDE-Q scores at EOT.

resultsWV positively predicted EDE-Q Global Score (p = 0.033, sr

conclusionsPatients who experience greater weight fluctuations early in treatment may be more susceptible to elevated psychopathology at discharge. In light of few significant effects and small effect sizes, more research is needed to determine the putative role of early weight trends in adolescent AN outcomes.

Indexed as

Anorexia NervosaBody WeightResidential TreatmentWeight GainAdolescentFemaleHumansMaleTreatment Outcomeadolescenceanorexia nervosahigher level of careweight changeweight variability

Identifiers

PMID40468841
PMCPMC13390974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.