ArticleChemistry & biodiversity2025
Volatilome and Antinociceptive Activity of the Traditional Preparation and Compounds from Ageratina grandifolia (Regel) R.M. King & H. Rob.
Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Volatilome and Antinociceptive Activity of the Traditional Preparation and Compounds from Ageratina grandifolia (Regel) R.M. King & H. Rob.Chemistry & biodiversity · 2025Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
An infusion of Ageratina grandifolia, a traditional preparation, and major compounds [3,5-diprenyl-4-hydroxyacetophenone (1), O-methylencecalinol (2), encecalin (3), and encecalinol (4)], tested at 10, 31.6, and 100 mg/kg, intragastrically administered, showed a significant antinociceptive effect in both phases of the formalin test in mice. Encecalinol (4) was the most active and showed a dose-dependent antinociceptive action in both phases; its effect was substantially attenuated when the mice were pretreated with naloxone. The volatile constituents of A. grandifolia, A. petiolaris, and A. espinosarum were established through gas chromatography-mass spectrometry analysis of the components obtained by head-space solid microextraction and hydrodistillation. The volatiles contained a high percentage of caryophyllene, germacrene D, spathulenol, and caryophyllene oxide; the most relevant difference was the presence of chromenes only in A. grandifolia. A suitable liquid chromatographic method was developed and validated to simultaneously quantify the three significant flavonoids in the ethyl acetate soluble fraction of the traditional preparation.
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