ArticleAnimal bioscience2025
Comparative analyses of serum parameters between nontransgenic and transgenic male chickens expressing the 3D8 single-chain variable fragment gene, and mortality and growth characteristics.
Article in Animal bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTransgenic (TG) animals offer significant potential for diverse applications but may pose risks if the impact of transgene expression on health and physiological parameters is not thoroughly assessed. This study aims to evaluate the effects of 3D8 scFv gene expression on male TG chickens, focusing on key biological markers, mortality, and growth.
methodsSerum samples were collected at 14 weeks of age from male TG and non-TG chickens for comprehensive analysis of serum biochemistry, sex hormones, and cytokine profiles. Mortality and growth were monitored over a 34-week period to assess long-term effects. Statistical comparisons were conducted between TG and non-TG groups to identify significant differences.
resultsThe results revealed that male TG chickens showed significantly lower serum levels of alanine aminotransferase, insulin-like growth factor-1, interferon-gamma, interleukin-4, and tumor necrosis factor-1 alpha compared to non-TG chickens (p<0.05). However, no significant differences in mortality or final body weight were observed between groups (p>0.05). These findings are consistent with previous results in female TG chickens, indicating that 3D8 gene expression does not adversely affect health or growth performance.
conclusion3D8 scFv gene expression in male TG chickens does not adversely affect mortality, growth, or serum parameters, indicating that the transgene does not have detrimental effects on these critical metrics in male chickens. These findings support the safety and physiological stability of 3D8 gene expression in TG animals.
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