Evidence map›Paper›PMID 40468722›Full record

ArticleCancer research and treatment2026

Discrepancy between Genetically Predicted and Observed Alcohol Intake and Its Impact on Gastric Cancer Susceptibility.

Ga-Eun Yie, Cheol Min Shin, Kyungtaek Park, Jinyeon Jo, Ah Ra Do, Sungkyoung Choi, Jung Hun Ohn, Sejoon Lee, Jeongseon Kim, Sun Ha Jee and 3 more

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Article in Cancer research and treatment, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Ga-Eun YieInterdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Korea.
Cheol Min ShinDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Kyungtaek ParkInstitute of Health and Environment, Seoul National University, Seoul, Korea.
Jinyeon JoDepartment of Public Health Sciences, Seoul National University, Seoul, Korea.
Ah Ra DoInterdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Korea.
Sungkyoung ChoiDepartment of Mathematical Data Science, Hanyang University (ERICA), Ansan, Korea.
Jung Hun OhnDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Sejoon LeePrecision Medicine Center, Seoul National University Bundang Hospital, Seongnam, Korea.
Jeongseon KimCenter for Gastric Cancer, National Cancer Center Hospital, National Cancer Center, Goyang, Korea.
Sun Ha JeeDepartment of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea.
Seung Joo KangDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Nayoung KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Sungho WonInterdisciplinary Program of Bioinformatics, Seoul National University, Seoul, Korea.

Funding

Ministry of Science and ICTNational Research Foundation of Korea RS-2024-00337453National Research Foundation of Korea RS-2024-00346850Seoul National University Bundang Hospital 02-2020-041Seoul National University Bundang Hospital 02-2023-0012Seoul National University Bundang Hospital 13-2019-001
6 · The paper itself

Abstract

purposeWe aimed to investigate how genetic predisposition to drinking and gastric cancer (GC) modifies the association between alcohol consumption and GC risk in the Korean population. MATERIALS AND

methodsPolygenic risk scores for GC (PRS-GC) and alcohol consumption (PRS-Alcohol) were formulated using genome-wide association results from BioBank Japan. Validation was performed using Korean cohorts (SNUBH-GENIE cohort), incorporating 8,846 controls and 531 patients with GC. Subsequently, these PRSs were applied to an independent Korean cohort of 67,771 participants, including 313 patients with GC during the follow-up for 14 years (KoGES cohort).

resultsIn KoGES cohort, the influence of alcohol consumption on GC risk was significantly altered by the PRS-GC and exhibited a synergistic interaction effect. PRS-Alcohol itself shows a negative correlation with GC risk. However, when actual alcohol consumption significantly exceeded genetically predicted levels, the risk of alcohol-related GC was notably increased (adjusted hazard ratio, 1.32; 95% confidence interval, 1.01 to 1.72). Heavy drinkers in the high-PRS-GC/low-PRS-Alcohol group had a 2.16 times higher risk of GC than non-to-light drinkers, which was prominent in males.

conclusionKorean drinkers with higher PRS-GC who consume alcohol more than genetically predicted levels are susceptible to GC. PRS-GC and PRS-Alcohol may be beneficial for assessing the impact of alcohol consumption on GC risk in Koreans.

Indexed as

Alcohol DrinkingGenetic Predisposition to DiseaseStomach NeoplasmsAdultAgedCase-Control StudiesFemaleGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideRepublic of KoreaRisk FactorsAlcohol drinkingGenetic risk scoreLauren classificationSexStomach neoplasms

Identifiers

PMID40468722
PMCPMC13093037

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.