Evidence map›Paper›PMID 40468616›Full record

ArticleAdvanced healthcare materials2025

Vorticity-Facilitated Platelet Aggregation: a High Expansion-Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis.

Jianfang Ren, Nurul Aisha Zainal Abidin, Allan Sun, Rui Gao, Yuxin Chen, Arian Nasser, Zihao Wang, Yunduo Charles Zhao, Alexander Dupuy, Anna Waterhouse and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jianfang RenSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Nurul Aisha Zainal AbidinSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Allan SunSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.ORCID https://orcid.org/0009-0004-1100-5111
Rui GaoSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Yuxin ChenSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Arian NasserSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Zihao WangSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.
Yunduo Charles ZhaoSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.ORCID https://orcid.org/0000-0002-1802-2318
Alexander DupuySchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.ORCID https://orcid.org/0009-0009-8315-5641
Anna WaterhouseCharles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.ORCID https://orcid.org/0000-0003-1498-9393
Qian Peter SuCharles Perkins Centre, The University of Sydney, Camperdown, NSW, 2006, Australia.ORCID https://orcid.org/0000-0001-7364-3945
Daniele VigoloSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.ORCID https://orcid.org/0000-0002-8265-9882
Mike Chia Lun WuSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.ORCID https://orcid.org/0000-0002-4039-4409
Lining Arnold JuSchool of Biomedical Engineering, Faculty of Engineering, The University of Sydney, Darlington, NSW, 2008, Australia.ORCID https://orcid.org/0000-0002-7591-0864

Funding

Australian Research Council DECRA PhD Scholarship DE230101128-J.R.MRFF Cardiovascular Health Mission MRF2016165- L.A.JMRFF Cardiovascular Health Mission MRF2023977- L.A.JMRFF Early to Mid Career Researchers M.C.L.W.MRFF Early to Mid Career Researchers MRF2028865- L.A.J.MRFF Early to Mid Career Researchers Q.P.SNational Heart Foundation Future Leader Fellowship 105863-L.A.J.National Heart Foundation of Australia Vanguard Grant 102592-Q.P.S.National Heart Foundation of Australia Vanguard Grant 106979-L.A.J.National Heart Foundation Postgraduate Scholarship 106879-Y.C.Z.NHMRC Ideas Grant APP2003904-L.A.J.NHMRC Ideas Grant Q.P.S.NHMRC Investigator Grant APP1177374-Q.P.S.NHMRC Postgraduate Scholarship GNT2022247-Y.C.Z.NSW Cardiovascular Capacity Building Program L.A.J.NSW Cardiovascular Capacity Building Program Q.P.SOffice of Global and Research Engagement InternationalSustainableDevelopmentGoalProgram-L.A.J.Ramaciotti Foundations 2020HIG76-L.A.JSnow Medical Fellowship 2022SF176-L.A.J.
6 · The paper itself

Abstract

Complex flow patterns play a critical role in arterial thrombosis, yet the specific contribution of vorticity-the rotational component of fluid flow-remains poorly understood. An innovative microfluidic platform with systematically varied expansion angles (β = 30°-150°) in a double stenosis design is developed to isolate vorticity's effects under controlled conditions. The high expansion-ratio device with sharp-angled geometries successfully generates distinct vortical flow patterns, confirmed through computational and experimental flow visualizations. Real-time confocal microscopy revealed a strong positive correlation (r = 0.6698) between vorticity magnitude and thrombus size, with high-vorticity conditions producing thrombi up to four times larger than low-vorticity settings. Mechanistic investigations demonstrated enhanced von Willebrand Factor (vWF) accumulation and platelet integrin activation in vortical environments. Platelets in high-vorticity regions exhibited integrin α

Indexed as

Lab-On-A-Chip DevicesMicrofluidicsPlatelet AggregationThrombosisBlood PlateletsHumansvon Willebrand Factorvon Willebrand Factorarterial thrombosismechanobiologymicrofluidicplatelet aggregationstenosisvorticity

Identifiers

PMID40468616
PMCPMC12581891

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.