ArticleCNS neuroscience & therapeutics2025
The Oxytocin Neurons in the Paraventricular Nucleus Are Essential for Chronic Sleep Deprivation-Mediated Anxiety-Related Behaviors.
Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Hypothalamic Oxytocinergic-Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon-Bone Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Paraventricular oxytocin neurons attenuate post-ischemic brain injury by suppressing microglia-mediated neuroinflammation.Cell communication and signaling : CCS · 2026Article
- PVNJournal of neuroinflammation · 2026Article
- Decreased Oxytocin Mediates PVN-CA2 and PVN-PrL in Sleep Deprivation-Induced Social Memory Deficits.Research (Washington, D.C.) · 2026Article
- A narrative review on oxytocin at the intersection of sleep, stress, and social behavior.Frontiers in neuroscience · 2026Review
- Sleep Deprivation Induces Anxiety-like Behaviors in Mice by Impairing ApoE/AMPK/mTOR-Mediated Autophagy.Molecular neurobiology · 2025Article
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Authors and funding
18 authors.
Funding
Abstract
aimsSleep disorders increase the risk of anxiety disorders. The underlying mechanisms and potential targets remain poorly understood. Our research aimed to discover the essential role of oxytocin neurons in the paraventricular nucleus (PVN
methodsIn vivo optogenetic stimulation was used to regulate the activity of PVN
resultsThrough c-Fos staining of the whole brain, we found that cSD decreased c-Fos expression in the PVN and increased c-Fos expression in the medial prefrontal cortex (mPFC). cSD promoted anxiety-related behaviors mainly through inhibiting AMPAR-mediated postsynaptic excitability of PVN
conclusionOur findings provide key mechanisms and promising deep brain stimulation strategies associated with synaptic plasticity for cSD-induced obsessive anxiety.
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